Evidence map›Paper›PMID 28440096›Full record

ReviewCritical reviews in microbiology2017

Strategies in Ebola virus disease (EVD) diagnostics at the point of care.

Chad T Coarsey, Nwadiuto Esiobu, Ramswamy Narayanan, Mirjana Pavlovic, Hadi Shafiee, Waseem Asghar

Abstract readReview
In one paragraph

Review in Critical reviews in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Metal Organic Frameworks as Biosensing Materials for COVID-19.Cellular and molecular bioengineering · 2021
    Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chad T Coarseya Department of Computer and Electrical Engineering & Computer Science , Florida Atlantic University , Boca Raton , FL , United States.ORCID http://orcid.org/0000-0002-7862-3094
Nwadiuto Esiobuc Department of Biological Sciences , Florida Atlantic University , Boca Raton , FL , United States.ORCID http://orcid.org/0000-0003-2164-0026
Ramswamy Narayananc Department of Biological Sciences , Florida Atlantic University , Boca Raton , FL , United States.ORCID http://orcid.org/0000-0001-9346-9083
Mirjana Pavlovica Department of Computer and Electrical Engineering & Computer Science , Florida Atlantic University , Boca Raton , FL , United States.ORCID http://orcid.org/0000-0003-2894-329X
Hadi Shafieed Division of Engineering in Medicine, Department of Medicine , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , United States.ORCID http://orcid.org/0000-0003-2240-7648
Waseem Asghara Department of Computer and Electrical Engineering & Computer Science , Florida Atlantic University , Boca Raton , FL , United States.ORCID http://orcid.org/0000-0003-0458-8430

Funding

Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
Development of disposable and refrigeration-free microchip technology for CD4+ T cell counting at point-of-care settingsR15AI127214 · NIAID · FLORIDA ATLANTIC UNIVERSITY · PI ASGHAR, WASEEM · 2016 to 2016
$460k
NIAID NIH HHS R01 AI118502NIAID NIH HHS R15 AI127214
6 · The paper itself

Abstract

Ebola virus disease (EVD) is a devastating, highly infectious illness with a high mortality rate. The disease is endemic to regions of Central and West Africa, where there is limited laboratory infrastructure and trained staff. The recent 2014 West African EVD outbreak has been unprecedented in case numbers and fatalities, and has proven that such regional outbreaks can become a potential threat to global public health, as it became the source for the subsequent transmission events in Spain and the USA. The urgent need for rapid and affordable means of detecting Ebola is crucial to control the spread of EVD and prevent devastating fatalities. Current diagnostic techniques include molecular diagnostics and other serological and antigen detection assays; which can be time-consuming, laboratory-based, often require trained personnel and specialized equipment. In this review, we discuss the various Ebola detection techniques currently in use, and highlight the potential future directions pertinent to the development and adoption of novel point-of-care diagnostic tools. Finally, a case is made for the need to develop novel microfluidic technologies and versatile rapid detection platforms for early detection of EVD.

Indexed as

Africa, WesternBiosensing TechniquesDisease OutbreaksDisease ProgressionEbolavirusGenome, ViralHemorrhagic Fever, EbolaHumansMolecular Diagnostic TechniquesPoint-of-Care SystemsReal-Time Polymerase Chain ReactionSurface Plasmon ResonancediagnosticsEbola virusimmunoassaymicrofluidicspolymerase chain reaction

Identifiers

PMID28440096
PMCPMC5653233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.