ArticleJournal of the Association for Research in Otolaryngology : JARO2017
The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136420 (Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Intra-individual consistency of vestibular perceptual thresholds.Attention, perception & psychophysics · 2024Article
- Your Vestibular Thresholds May Be Lower Than You Think: Cognitive Biases in Vestibular Psychophysics.American journal of audiology · 2023Article
- Vestibular Precision at the Level of Perception, Eye Movements, Posture, and Neurons.Neuroscience · 2021Review
- The Influence of Altered-Gravity on Bimanual Coordination: Retention and Transfer.Frontiers in physiology · 2021Article
- Human vestibular perceptual thresholds for pitch tilt are slightly worse than for roll tilt across a range of frequencies.Experimental brain research · 2020Article
- The motor vertical in the absence of gravicentric cues.NPJ microgravity · 2020Article
- The influence of target distance on perceptual self-motion thresholds and the vestibulo-ocular reflex during interaural translation.Progress in brain research · 2019Article
- Human manual control precision depends on vestibular sensory precision and gravitational magnitude.Journal of neurophysiology · 2018Article
- Variability in the Vestibulo-Ocular Reflex and Vestibular Perception.Neuroscience · 2018Article
- Perception of threshold-level whole-body motion during mechanical mastoid vibration.Journal of vestibular research : equilibrium & orientation · 2018Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine (P = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have functional implications, e.g., during driving, bicycling, and piloting tasks. Differing results from some past studies of promethazine on the vestibulo-ocular reflex emphasize the need to study motion perception in addition to motor responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.