ArticleEuropean radiology2017
Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in hypertension and associated with left ventricular remodeling.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prognostic value of cardiac magnetic resonance in patients with aortic stenosis: A systematic review and meta-analysis.PloS one · 2022Pooled it
- CMR publications from China of the last more than 30 years.The international journal of cardiovascular imaging · 2020Pooled it
- Point estimate and reference normality interval of MRI-derived myocardial extracellular volume in healthy subjects: a systematic review and meta-analysis.European radiology · 2019Pooled it
- Prognostic value of T1 mapping and extracellular volume fraction in cardiovascular disease: a systematic review and meta-analysis.Heart failure reviews · 2018Pooled it
- Subclinical Cardiac Remodeling in Borderline Hypertension: The Role of Advanced Imaging.Cureus · 2026Review
- Does adding a delayed phase to cardiac computed tomography for coronary artery evaluation have prognostic value?European heart journal. Cardiovascular Imaging · 2026Article
- Minimally Invasive Free-Breathing Gating-Free Extracellular Cellular Volume Quantification for Repetitive Myocardial Fibrosis Evaluation in Rodents.Biomolecules · 2025Article
- Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR.European radiology · 2023Article
- Role of cardiovascular magnetic resonance in the clinical evaluation of left ventricular hypertrophy: a 360° panorama.The international journal of cardiovascular imaging · 2023Review
- Hemoglobin A1c in type 2 diabetes mellitus patients with preserved ejection fraction is an independent predictor of left ventricular myocardial deformation and tissue abnormalities.BMC cardiovascular disorders · 2023Article
- Occurrence and morphology of ventricular arrhythmias in apparently normal hearts in relation to late gadolinium enhancement on cardiovascular magnetic resonance.The international journal of cardiovascular imaging · 2022Article
- Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults.PloS one · 2022Article
- Detection of myocardial fibrosis: Where we stand.Frontiers in cardiovascular medicine · 2022Review
- Comprehensive assessment of hypertensive heart disease: cardiac magnetic resonance in focus.Heart failure reviews · 2021Review
- T-wave and its association with myocardial fibrosis on cardiovascular magnetic resonance examination.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Detection of Myocardial Fibrosis and Left Ventricular Dysfunction with Cardiac MRI in a Hypertensive Swine Model.Radiology. Cardiothoracic imaging · 2020Article
- Early detection of left atrial dysfunction assessed by CMR feature tracking in hypertensive patients.European radiology · 2020Article
- Extracellular volume fraction assessed using cardiovascular magnetic resonance can predict improvement in left ventricular ejection fraction in patients with dilated cardiomyopathy.Heart and vessels · 2018Observational
- Differential diagnosis of thickened myocardium: an illustrative MRI review.Insights into imaging · 2018Review
- An Intervention Target for Myocardial Fibrosis: Autophagy.BioMed research international · 2018Review
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo determine whether extracellular volume fraction (ECV) quantification by cardiac magnetic resonance (CMR) can demonstrate left ventricle (LV) abnormalities and relationship between ECV and LV remodeling in hypertension (HTN) patients
methodsECV quantification was prospectively performed in 134 consecutive HTN patients and 97 healthy subjects. Individual and regional ECV were compared to the regions on late gadolinium enhancement (LGE) images. Statistical analysis of the relationship between LV global functional parameters and ECV was carried out using Pearson's correlation, Student's t test and multiple regressions.
resultsIn the HTN group, 70.1% (94/134) were LGE negative and 29.9% (40/134) LGE positive. The mean ECV after adjusting for age, sex, BMI, diabetes, smoking and dyslipidaemia in healthy controls and LGE-negative patients were 26.9 ± 2.67% and 28.5 ± 2.9% (p < 0.001), respectively. The differences in ECV reached statistical significance among the regions of LGE, LGE-Peri, LGE remote and the normal area between the control and LGE-positive subgroup (all p < 0.05). Global ECV significantly correlated with LVEF (r = -0.466, p < 0 .001) and LV hypertrophy (r = 0.667, p < 0.001).
conclusionsECV can identify LV abnormalities at an early stage in HTN patients without LGE. These abnormalities may reflect an increase in diffuse myocardial fibrosis and are associated with LV remodeling. KEY POINTS: • Diffuse myocardial fibrosis may develop in hypertensive cardiomyopathy before conventional MRI detectable LGE. • ECV can identify myocardial fibrosis at an early stage in hypertensive patients. • Elevated ECV is associated with decreased LV global function and LV remodeling in hypertension.
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