ArticleScience advances2016
The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 169 citations in OpenAlex.
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Conserved and lineage-specific mechanisms drive chromatophore differentiation in reptiles.Nature communications · 2026Article
- Hoxc13 and homologs of mammalian hair keratins are required for the cornification of nuptial pads in Xenopus frogs.Communications biology · 2026Article
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Article
- Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head.iScience · 2025Article
- Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth.Developmental biology · 2025Review
- Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding.Open biology · 2025Article
- Papillary and Callous Scales in the Integument of Agamid Lizards (Agamidae, Sauria) as a Phenomenon of Extraordinary Development of the Corneous Layers.Animals : an open access journal from MDPI · 2025Article
- In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken.PLoS biology · 2025Article
- Article
- Hydrocortisone treatment as a tool to study conjunctival placode induction.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Ancient skin sported intricately patterned scales.Nature · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Transcriptomic and proteomic strategies to reveal the mechanism of Gymnocypris przewalskii scale development.BMC genomics · 2024Article
- Microstructural architecture of the bony scutes, spine, and rays of the bony fins in the common plecoInternational journal of veterinary science and medicine · 2024Article
- The mechanoreceptors in hatchling and adult Elasmobranch skin.microPublication biology · 2024Article
- Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts.Development (Cambridge, England) · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most mammals, birds, and reptiles are readily recognized by their hairs, feathers, and scales, respectively. However, the lack of fossil intermediate forms between scales and hairs and substantial differences in their morphogenesis and protein composition have fueled the controversy pertaining to their potential common ancestry for decades. Central to this debate is the apparent lack of an "anatomical placode" (that is, a local epidermal thickening characteristic of feathers' and hairs' early morphogenesis) in reptile scale development. Hence, scenarios have been proposed for the independent development of the anatomical placode in birds and mammals and parallel co-option of similar signaling pathways for their morphogenesis. Using histological and molecular techniques on developmental series of crocodiles and snakes, as well as of unique wild-type and EDA (ectodysplasin A)-deficient scaleless mutant lizards, we show for the first time that reptiles, including crocodiles and squamates, develop all the characteristics of an anatomical placode: columnar cells with reduced proliferation rate, as well as canonical spatial expression of placode and underlying dermal molecular markers. These results reveal a new evolutionary scenario where hairs, feathers, and scales of extant species are homologous structures inherited, with modification, from their shared reptilian ancestor's skin appendages already characterized by an anatomical placode and associated signaling molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.