ArticleAlzheimer's & dementia (New York, N. Y.)2017
Recruiting to preclinical Alzheimer's disease clinical trials through registries.
Article in Alzheimer's & dementia (New York, N. Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Ethical issues in genomics research in persons with Alzheimer's Disease/Alzheimer's Disease-related dementia (AD/ADRD): a systematic review.BMC medical ethics · 2024Pooled it
- Effectiveness of a local recruitment registry in older adults in Southern California.BMC medical research methodology · 2025Article
- Recruiting Persons with Dementia and Caregivers in a Clinical Trial: Dyads Perceptions.Western journal of nursing research · 2022Article
- Subjective Cognitive Decline in a Registry Sample: Relation to Psychiatric History, Loneliness, and Personality.The journal of prevention of Alzheimer's disease · 2022Article
- Diversifying Recruitment Registries: Considering Neighborhood Health Metrics.The journal of prevention of Alzheimer's disease · 2022Article
- Early Implementation and Evaluation of StepUp for Dementia Research: An Australia-Wide Dementia Research Participation and Public Engagement Platform.International journal of environmental research and public health · 2021Article
- Asian Americans and Pacific Islanders' perspectives on participating in the CARE recruitment research registry for Alzheimer's disease and related dementias, aging, and caregiving research.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Pilot study of an Alzheimer's disease risk assessment program in a primary care setting.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings.Alzheimer's research & therapy · 2020Article
- Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.NeuroImage · 2019Article
- Genomic variant sharing: a position statement.Wellcome open research · 2019Article
- Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46.BMC research notes · 2018Article
- Patient Engagement: The Fundació ACE Framework for Improving Recruitment and Retention in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2018Review
- Comparing research attitudes in Down syndrome and non-Down syndrome research decision-makers.Alzheimer's & dementia (New York, N. Y.)Article
- Evaluation of efficiency and effectiveness of different recruitment strategies for the FINGER-NL multidomain lifestyle intervention trial via the Dutch Brain Research Registry.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Participant registries are repositories of individuals who have expressed willingness to learn about studies for which they may be eligible. Registries are increasingly being utilized to improve recruitment to preclinical Alzheimer's disease (AD) clinical trials, which require large screening efforts to identify adequate numbers of participants who meet enrollment criteria. Recruiting to preclinical AD trials from registries is made more efficient through registry collection of data that permits exclusion of those who will not be eligible and identifies individuals most likely to qualify for trials. Such data could include self-reported disease family history or other risk factors, but could also include cognitive, genetic, or biomarker testing outcomes. Few data are available to guide investigators overseeing registries and important ethical questions are likely to arise related to their conduct, especially in registries collecting AD risk information. This article outlines three areas of consideration for registry investigators: informed consent, disclosure, and sponsorship.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.