Evidence map›Paper›PMID 28439519›Full record

ArticleNeurophotonics2017

Structured illumination diffuse optical tomography for noninvasive functional neuroimaging in mice.

Matthew D Reisman, Zachary E Markow, Adam Q Bauer, Joseph P Culver

Open access · hybridAbstract read
In one paragraph

Article in Neurophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neurophotonics · 2020
    Article
  6. Article
  7. Altered hemodynamics contribute to local but not remote functional connectivity disruption due to glioma growth.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  8. Article
  9. Review
  10. Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew D ReismanWashington University in St. Louis, Department of Physics, St. Louis, Missouri, United States.
Zachary E MarkowWashington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States.
Adam Q BauerWashington University School of Medicine, Department of Radiology, St. Louis, Missouri, United States.
Joseph P CulverWashington University in St. Louis, Department of Physics, St. Louis, Missouri, United States.
Washington University in St. Louis · US

Funding

IMAGING COREP01NS080675 · NINDS · WASHINGTON UNIVERSITY · PI SNYDER, ABRAHAM ZVI · 2013 to 2017
$6.2M
High-Sensitivity DOT for Mapping Human Brain FunctionR01NS090874 · NINDS · WASHINGTON UNIVERSITY · PI CULVER, JOSEPH P · 2014 to 2025
$5.5M
MAPPING FUNCTIONAL CONNECTIVITY WITH FLUORESCENCE MOLECULAR TOMOGRAPHYR01NS099429 · NINDS · WASHINGTON UNIVERSITY · PI CULVER, JOSEPH P · 2017 to 2021
$2.9M
OPTICAL IMAGING AND FUNCTIONAL CONNECTIVITY MAPPING FOR MICER01NS078223 · NINDS · WASHINGTON UNIVERSITY · PI CULVER, JOSEPH P · 2012 to 2016
$2.7M
INFLUENCE OF INTERHEMISPHERIC CONNECTIVITY ON RECOVERY AFTER FOCAL ISCHEMIAR01NS084028 · NINDS · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2013 to 2017
$2.2M
MECHANISMS OF FUNCTIONAL AND BEHAVIORAL RECOVERY FOLLOWING ISCHEMIC STROKEK25NS083754 · NINDS · WASHINGTON UNIVERSITY · PI BAUER, ADAM Q · 2014 to 2018
$756k
NINDS NIH HHS K25 NS083754NINDS NIH HHS P01 NS080675NINDS NIH HHS R01 NS078223NINDS NIH HHS R01 NS084028NINDS NIH HHS R01 NS090874NINDS NIH HHS R01 NS099429
6 · The paper itself

Abstract

Optical intrinsic signal (OIS) imaging has been a powerful tool for capturing functional brain hemodynamics in rodents. Recent wide field-of-view implementations of OIS have provided efficient maps of functional connectivity from spontaneous brain activity in mice. However, OIS requires scalp retraction and is limited to superficial cortical tissues. Diffuse optical tomography (DOT) techniques provide noninvasive imaging, but previous DOT systems for rodent neuroimaging have been limited either by sparse spatial sampling or by slow speed. Here, we develop a DOT system with asymmetric source-detector sampling that combines the high-density spatial sampling (0.4 mm) detection of a scientific complementary metal-oxide-semiconductor camera with the rapid (2 Hz) imaging of a few ([Formula: see text]) structured illumination (SI) patterns. Analysis techniques are developed to take advantage of the system's flexibility and optimize trade-offs among spatial sampling, imaging speed, and signal-to-noise ratio. An effective source-detector separation for the SI patterns was developed and compared with light intensity for a quantitative assessment of data quality. The light fall-off versus effective distance was also used for

Indexed as

diffuse optical tomographyfunctional neuroimagingnoninvasive imagingoptical imagingstructured illumination

Identifiers

PMID28439519
PMCPMC5391480
OpenAlexW2605946417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.