ReviewFrontiers in cellular and infection microbiology2017
Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases.
Review in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 266 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
266 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tick Diversity, Emerging Tick-Borne Pathogens, and Public Health Implications Across Africa: A Systematic Review.Acta parasitologica · 2025Pooled it
- Hepatozoon (Eucoccidiorida: Hepatozoidae) in wild mammals of the Americas: a systematic review.Parasites & vectors · 2024Pooled it
- Review
- Metagenomic analysis of the midgut microbiome in Dermacentor abaensis ticks at different feeding states.Experimental & applied acarology · 2026Article
- Article
- Diversity and Occurrence of Tick-Borne Pathogens in Small Ruminants and Their Ticks in Sardinia: Implications for Animal Health and Zoonotic Risk.Veterinary sciences · 2026Article
- Crimean-Congo hemorrhagic fever virus in the last four decades (1981-2025): global output, collaboration networks, and emerging frontiers.Tropical animal health and production · 2026Article
- Molecular detection of Bartonella species and Coxiella endosymbiont in human-biting Haemaphysalis longicornis ticks in Korea.Parasites, hosts and diseases · 2026Article
- Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line.Medical and veterinary entomology · 2026Article
- Colpodellosis: IsPathogens (Basel, Switzerland) · 2026Review
- Current Knowledge on Tick-Borne Encephalitis Virus Interaction with Ticks: Acquisition, Dissemination, and Persistence.Pathogens (Basel, Switzerland) · 2026Review
- Accelerating Progress on Ticks and Tick-Borne Diseases in Southeast Asia: Regional Challenges, Evidence Gaps, and Priorities (2023-2025).Pathogens (Basel, Switzerland) · 2026Article
- Molecular detection and characterization of Anaplasma phagocytophilum-related strains and Hepatozoon spp. in domestic cats in eastern Türkiye.BMC veterinary research · 2026Article
- Surveillance of tick-borne pathogens in ticks collected from Swiss residents.Parasites & vectors · 2026Article
- Ecological Frameworks of Pathogen-Pathogen and Pathogen-Microbiome Interactions Within the Tick Holobiont.Pathogens (Basel, Switzerland) · 2026Review
- A Bayesian modelling framework for estimating tick-borne pathogen transmission dynamics at the host-tick interface.PLoS computational biology · 2026Article
- Ticks and tick-borne diseases: A call for comprehensive tick surveillance in India under One Health approach.The Indian journal of medical research · 2026Review
- Molecular screening of tick-borne pathogens in host-seeking Haemaphysalis punctata Canestrini & Fanzago, 1878 (Ixodoidea: Ixodidae) in Anatolia with the first report of Burana virus.Parasites & vectors · 2026Article
- Article
- A novel ecotype of Anaplasma phagocytophilum complex in questing Ixodes fuscipes ticks.Parasites & vectors · 2026Article
206 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.