Evidence map›Paper›PMID 28439315›Full record

ArticleClinical epigenetics2017

36 h fasting of young men influences adipose tissue DNA methylation of

Line Hjort, Sine W Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A Vaag, Charlotte Ling

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 60 citations in OpenAlex.

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  11. Fasting influences aquaporin expression, water transport and adipocyte metabolism in the peritoneal membrane.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Line HjortDepartment of Endocrinology (Diabetes and Metabolism), Rigshospitalet, section 7652, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
Sine W JørgensenDepartment of Endocrinology (Diabetes and Metabolism), Rigshospitalet, section 7652, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
Linn GillbergDepartment of Endocrinology (Diabetes and Metabolism), Rigshospitalet, section 7652, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
Elin HallEpigenetics and Diabetes and Islet Cell Exocytosis, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Jan Waldentröms gata 35, SE-20502 Malmö, Sweden.
Charlotte BrønsDepartment of Endocrinology (Diabetes and Metabolism), Rigshospitalet, section 7652, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
Jan FrystykInstitute of Clinical Medicine, University of Aarhus, Aarhus, Denmark.
Allan A VaagDepartment of Endocrinology (Diabetes and Metabolism), Rigshospitalet, section 7652, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
Charlotte LingEpigenetics and Diabetes and Islet Cell Exocytosis, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Jan Waldentröms gata 35, SE-20502 Malmö, Sweden.
Rigshospitalet · DKLund University · SEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects. However, the molecular mechanisms explaining these metabolic differences remain unknown. Environmental influences may dynamically affect epigenetic marks, also in postnatal life. Here, we aimed to study the effects of short-term fasting on leptin (

methodsTwenty-one young LBW men and 18 matched NBW controls were studied during 36 h fasting. Eight subjects from each group completed a control study (overnight fast). We analyzed SAT

resultsAfter overnight fast (control study),

conclusionsThis is the first study to demonstrate that fasting induces changes in DNA methylation. This was shown in

Indexed as

AdiponectinAdultBirth WeightDNA MethylationEpigenesis, GeneticFastingGene Expression RegulationHumansLeptinMalePromoter Regions, GeneticSubcutaneous FatYoung AdultAdiponectinADIPOQ protein, humanLeptinAdiponectinAdipose tissueEpigeneticsFastingLeptinLow birth weightType 2 diabetes

Identifiers

PMID28439315
PMCPMC5399392
OpenAlexW2607248396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.