Evidence map›Paper›PMID 28439258›Full record

ReviewFrontiers in endocrinology2017

Diabetic Cardiomyopathy: An Immunometabolic Perspective.

Paras K Mishra, Wei Ying, Shyam Sundar Nandi, Gautam K Bandyopadhyay, Kaushik K Patel, Sushil K Mahata

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Why the diabetic heart is energy inefficient: a ketogenesis and ketolysis perspective.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  17. Article
  18. Article
  19. Yes-Associated Protein is Involved in Myocardial Fibrosis in Rats with Diabetic Cardiomyopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paras K MishraDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Wei YingDepartment of Medicine, Metabolic Physiology and Ultrastructural Biology Laboratory, University of California San Diego, La Jolla, CA, USA.
Shyam Sundar NandiDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Gautam K BandyopadhyayDepartment of Medicine, Metabolic Physiology and Ultrastructural Biology Laboratory, University of California San Diego, La Jolla, CA, USA.
Kaushik K PatelDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Sushil K MahataDepartment of Medicine, Metabolic Physiology and Ultrastructural Biology Laboratory, University of California San Diego, La Jolla, CA, USA.
University of California, San Diego · USUniversity of Nebraska Medical Center · US

Funding

The Role of Excitatory Input into the PVN on Increased Sympathetic Drive in HeartP01HL062222 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHULTZ, HAROLD D · 1999 to 2019
$32.2M
Inflammation, miRNA and autophagy in diabetesR01HL113281 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MISHRA, PARAS KUMAR · 2013 to 2017
$1.9M
Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfuncR01HL116205 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MISHRA, PARAS KUMAR · 2013 to 2017
$1.9M
Role of HIF1-alpha and Renal afferents in Activation of the PVN in Heart FailureR56HL124104 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PATEL, KAUSHIK P · 2014 to 2014
$354k
NHLBI NIH HHS P01 HL062222NHLBI NIH HHS R01 HL113281NHLBI NIH HHS R01 HL116205NHLBI NIH HHS R56 HL124104
6 · The paper itself

Abstract

The heart possesses a remarkable inherent capability to adapt itself to a wide array of genetic and extrinsic factors to maintain contractile function. Failure to sustain its compensatory responses results in cardiac dysfunction, leading to cardiomyopathy. Diabetic cardiomyopathy (DCM) is characterized by left ventricular hypertrophy and reduced diastolic function, with or without concurrent systolic dysfunction in the absence of hypertension and coronary artery disease. Changes in substrate metabolism, oxidative stress, endoplasmic reticulum stress, formation of extracellular matrix proteins, and advanced glycation end products constitute the early stage in DCM. These early events are followed by steatosis (accumulation of lipid droplets) in cardiomyocytes, which is followed by apoptosis, changes in

Indexed as

cardiomyopathyfat metabolismglucose metabolisminflammationinnate and adaptive immunityinsulin resistancemiRNAobesity

Identifiers

PMID28439258
PMCPMC5384479
OpenAlexW2604978076

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.