ReviewFrontiers in neurology2017
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Endoscopic versus catheter-based minimally invasive evacuation of spontaneous supratentorial intracerebral hemorrhage: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Efficacy of desferrioxamine mesylate in intracerebral hematoma: a systemic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.Clinical pharmacology in drug development · 2021Trial
- Temporal Profile of Soluble TLR4 and its Association with Intracerebral Haemorrhage Expansion.Translational stroke research · 2026Article
- Lyophilized platelet derived extracellular vesicles promote hemostasis and attenuate intracranial hemorrhage following traumatic brain injury.Journal of translational medicine · 2026Article
- Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.Translational stroke research · 2026Article
- Article
- Deep learning-based imaging model to predict early hematoma enlargement and hospital mortality in spontaneous intracerebral hemorrhage.World journal of radiology · 2026Article
- Early Predictors of Long-Term Outcome in Basilar Artery Occlusion: A Post Hoc Analysis of the ATTENTION Trial.Journal of stroke · 2026Article
- Postoperative Rebleeding: The Sword of Damocles in Minimally Invasive Surgery for Intracerebral Hemorrhage.Research (Washington, D.C.) · 2026Review
- Perihematomal Edema Characteristics After Minimally Invasive Surgery in Intracerebral Hemorrhage.Critical care explorations · 2025Observational
- snRNA-seq reveals key transcription factors in the inflammatory response of microglia after intracerebral hemorrhage.Scientific reports · 2025Article
- Prognostic Role of Cuproptosis-Related Gene after Intracerebral Hemorrhage in Mice.Cellular and molecular neurobiology · 2025Article
- Fibrinogen-to-Albumin Ratio as a Novel Predictor of Intracerebral Hemorrhage in Maintenance Hemodialysis Patients.Journal of inflammation research · 2025Article
- Treatment and prognosis analysis of patients with moderate-volume hypertensive basal ganglia haemorrhage using DTI-guided stereotactic puncture-based surgery.Frontiers in neurology · 2025Article
- Influencing factors of futile recanalization after endovascular intervention in patients with acute basilar artery occlusion.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Association between white blood cells and ultra-early hematoma growth in patients with spontaneous intracerebral hemorrhage.Heliyon · 2024Article
- Time-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome.Diagnostics (Basel, Switzerland) · 2024Article
- Standard b-value DWI-derived stiffness index analysis may provide a way to evaluate the development of intracerebral hematoma.Frontiers in neurology · 2024Article
- Unveiling the significance of TREM1/2 in hemorrhagic stroke: structure, function, and therapeutic implications.Frontiers in neurology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth. Although death may occur at the time of the hemorrhage, delayed neurologic deterioration frequently occurs with hematoma growth and neuronal injury of the surrounding tissue. Perihematoma edema has also been implicated as a contributing factor for delayed neurologic deterioration after ICH. Cerebral edema results from both blood-brain barrier disruption and local generation of osmotically active substances. Inflammatory cellular mediators, activation of the complement, by-products of coagulation and hemolysis such as thrombin and fibrin, and hemoglobin enter the brain and induce a local and systemic inflammatory reaction. These complex cascades lead to apoptosis or neuronal injury. By identifying the major modulators of cerebral edema after ICH, a therapeutic target to counter degenerative events may be forthcoming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.