ArticleFrontiers in neuroscience2017
Outer Hair Cell and Auditory Nerve Function in Speech Recognition in Quiet and in Background Noise.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01781039 (Investigation of Anatomical Correlates of Speech Discrimination), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Anatomical Correlates of Speech Discrimination
Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Single Intratympanic Injection of Proprietary Brain-Derived Neurotrophic Factor (OTO-413) in Subjects with Speech-in-Noise Hearing Impairment: a Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Trial
- A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss.Nature communications · 2024Trial
- Early Detection of Blast-Induced Hidden Hearing Loss in Military Personnel Using an Extended Audiological Battery.Diagnostics (Basel, Switzerland) · 2026Article
- Is allergic rhinitis associated with hidden hearing loss in pediatric/adolescent patients? A cross-sectional study.Frontiers in pediatrics · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Notched noise reveals differential improvement in the neural representation of the sound envelope.Communications biology · 2025Article
- Inflection points in hearing deterioration: clinical characteristics of NIHL from steady-state noise exposure.International journal of occupational medicine and environmental health · 2025Article
- The relationship and interdependence of auditory thresholds, proposed behavioural measures of hidden hearing loss, and physiological measures of auditory function.International journal of audiology · 2025Article
- Changing Knowledge, Principles, and Technology in Contemporary Clinical Audiological Practice: A Narrative Review.Journal of clinical medicine · 2024Review
- Listening with an Ageing Brain - a Cognitive Challenge.Laryngo- rhino- otologie · 2023Review
- Noise Exposure in Palestinian Workers Without a Diagnosis of Hearing Impairment: Relations to Speech-Perception-in-Noise Difficulties, Tinnitus, and Hyperacusis.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design.Antioxidants & redox signaling · 2022Review
- Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss.Frontiers in physiology · 2022Article
- Speech Recognition During Follow-Up of Patients with Ménière's Disease: What Are We Missing?The journal of international advanced otology · 2022Article
- The Effect of Lifetime Noise Exposure and Aging on Speech-Perception-in-Noise Ability and Self-Reported Hearing Symptoms: An Online Study.Frontiers in aging neuroscience · 2022Article
- Verification of a Mobile Psychoacoustic Test System.Audiology research · 2021Article
- Inaccurate cortical tracking of speech in adults with impaired speech perception in noise.Brain communications · 2021Article
- Occupational Noise: Auditory and Non-Auditory Consequences.International journal of environmental research and public health · 2020Review
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms.Cold Spring Harbor perspectives in medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to describe the contribution of outer hair cells (OHCs) and the auditory nerve (AN) to speech understanding in quiet and in the presence of background noise. Fifty-three human subjects with hearing ranging from normal to moderate sensorineural hearing loss were assayed for both speech in quiet (Word Recognition) and speech in noise (QuickSIN test) performance. Their scores were correlated with OHC function as assessed via distortion product otoacoustic emissions, and AN function as measured by amplitude, latency, and threshold of the VIIIth cranial nerve Compound Action Potential (CAP) recorded during electrocochleography (ECochG). Speech and ECochG stimuli were presented at equivalent sensation levels in order to control for the degree of hearing sensitivity across patients. The results indicated that (1) OHC dysfunction was evident in the lower range of normal audiometric thresholds, which demonstrates that OHC damage can produce "Hidden Hearing Loss," (2) AN dysfunction was evident beginning at mild levels of hearing loss, (3) when controlled for normal OHC function, persons exhibiting either high or low ECochG amplitudes exhibited no statistically significant differences in neither speech in quiet nor speech in noise performance, (4) speech in noise performance was correlated with OHC function, (5) hearing impaired subjects with OHC dysfunction exhibited better speech in quiet performance at or near threshold when stimuli were presented at equivalent sensation levels. These results show that OHC dysfunction contributes to hidden hearing loss, OHC function is required for optimum speech in noise performance, and those persons with sensorineural hearing loss exhibit better word discrimination in quiet at or near their audiometric thresholds than normal listeners.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.