Evidence map›Paper›PMID 28439141›Full record

ArticleJournal of heterocyclic chemistry2017

Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine.

Ujjal Sarkar, Roman Hillebrand, Kevin M Johnson, Andrea H Cummings, Ngoc Linh Phung, Anuruddha Rajapakse, Haiying Zhou, Jordan R Willis, Charles L Barnes, Kent S Gates

Open access · bronzeAbstract read
In one paragraph

Article in Journal of heterocyclic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. 3-Substituted Blatter Radicals: Cyclization ofThe Journal of organic chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ujjal Sarkar *University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Roman Hillebrand *University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Kevin M JohnsonUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Andrea H CummingsUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Ngoc Linh PhungUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Anuruddha RajapakseUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Haiying ZhouUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Jordan R WillisUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Charles L BarnesUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
Kent S GatesUniversity of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.
University of Missouri · US

Funding

DNA Damage by Tumor Cell-Specific N-OxidesR01CA100757 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GATES, KENT S · 2003 to 2006
$677k
NCI NIH HHS R01 CA100757
6 · The paper itself

Abstract

Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-, 6-, and 7-positions.

Identifiers

PMID28439141
PMCPMC5400285
OpenAlexW2263832262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.