SynthesisMolecular psychiatry2018
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 16 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 16 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
235 citing papers in PubMed, 16 syntheses or guidelines pooled it.
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- A review of the 257 meta-analyses of the differences between females and males in prevalence and risk, protective factors, and treatment outcomes for mental disorder.BMC psychiatry · 2025Pooled it
- Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.BMC psychiatry · 2025Pooled it
- The Association between Post-Traumatic Stress Disorder, 5HTTLPR, and the Role of Ethnicity: A Meta-Analysis.Genes · 2024Pooled it
- The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Nature human behaviour · 2024Pooled it
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.Molecular psychiatry · 2023Pooled it
- Applications of Mendelian randomization in psychiatry: a comprehensive systematic review.Psychiatric genetics · 2022Pooled it
- Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.Biological psychiatry · 2022Pooled it
- Altered gene expression and PTSD symptom dimensions in World Trade Center responders.Molecular psychiatry · 2022Pooled it
- Phenotypic and genetic analysis of a wellbeing factor score in the UK Biobank and the impact of childhood maltreatment and psychiatric illness.Translational psychiatry · 2022Pooled it
- Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.Molecular psychiatry · 2021Pooled it
- Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder.Journal of traumatic stress · 2020Pooled it
- International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.Nature communications · 2019Pooled it
- GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis.Journal of affective disorders · 2019Pooled it
- Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.Epigenomics · 2018Pooled it
- An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort.Scientific reports · 2019Trial
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Causal effect heterogeneity estimation using summary statistics.Research square · 2026Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors.
L E DuncanDepartment of Psychiatry, Stanford University, Stanford, CA, USA.
A RatanatharathornDepartment of Epidemiology, Columbia University, New York, NY, USA.
A E AielloDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, NC, USA.
L M AlmliDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
A B AmstadterDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
A E Ashley-KochDepartment of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
D G BakerVeterans Affairs San Diego Healthcare System and Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
J C BeckhamVeterans Affairs Durham Healthcare System, Durham, NC, USA.
L J BierutDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
J BissonDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
B BradleyAtlanta VA Medical Center, Atlanta, GA, USA.
C-Y ChenThe Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
S DalvieDivision of Human Genetics, University of Cape Town, Cape Town, South Africa.
L A FarrerBiomedical Genetics, Boston University School of Medicine, Boston, MA, USA.
S GaleaBoston University School of Public Health, Boston, MA, USA.
M E GarrettDepartment of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
J E GelernterDepartment of Psychiatry, Yale University School of Medicine and VA CT Healthcare System, New Haven, CT, USA.
G GuffantiDepartment of Psychiatry, Harvard University, Cambridge, MA, USA.
M A HauserDepartment of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-2667-5420
E O JohnsonRTI International, Research Triangle Park, NC, USA.
R C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
N A KimbrelVeterans Affairs Durham Healthcare System, Durham, NC, USA.
A KingDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
N KoenDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
H R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
M W LogueVA Boston Healthcare System, Jamaica Plain, MA, USA.
A X MaihoferDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
A R MartinBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Boston, MA, USA.
M W MillerVA Boston Healthcare System, Jamaica Plain, MA, USA.ORCID 0000-0001-6393-8563
R A MoreyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
N R NugentDivision of Behavioral Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
J P RiceDepartment of Psychiatry, Washington University, St Louis, MO, USA.
S RipkeBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Boston, MA, USA.
A L RobertsDepartment of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health Cambridge, MA, USA.ORCID 0000-0001-6393-8563
N L SacconeDepartment of Genetics, Washington University, St Louis, MO, USA.
J W SmollerBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Boston, MA, USA.
D J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
M B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
J A SumnerCenter for Cardiovascular Behavioral Health, Columbia University Medical Center, New York, NY, USA.
M UddinDepartment of Psychology and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
R J UrsanoCenter for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
D E WildmanDepartment of Molecular & Integrative Physiology and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
R YehudaJames J. Peters Bronx Veterans Affairs and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.
H ZhaoDepartment of Biostatistics, Yale University, New Haven, CT, USA.
M J DalyBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Boston, MA, USA.ORCID 0000-0002-0949-8752
I LiberzonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-4990-556X
K J ResslerDepartment of Psychiatry, Harvard University, Cambridge, MA, USA.
C M NievergeltVeterans Affairs San Diego Healthcare System and Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
K C KoenenBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Boston, MA, USA.
Funding
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6MPsychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M2/4-Psychiatric GWAS Consortium: Genomic Follow-Up Next-Gen Sequencing & GenotypiU01MH094432 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2012 to 2015
$3.0M3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7MThe Genetics of Negative Conflict BehaviorR01MH079806 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MILLER, MARK W · 2007 to 2011
$1.5MResearch and Mentoring on Integrating Psychiatric Genetics and NeuroscienceK24MH094614 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SMOLLER, JORDAN W · 2012 to 2016
$925kThe Structure of PTSD ComorbidityI01CX000431 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MILLER, MARK W · 2011 to 2014
–Analysis of RORA and other candidate genes in PTSDI01BX002150 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MILLER, MARK W · 2013 to 2015
–BLRD VA I01 BX002150CSRD VA I01 CX000431NICHD NIH HHS P2C HD050924NIMH NIH HHS K24 MH094614NIMH NIH HHS R01 MH079806NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH111671NIMH NIH HHS U01 MH094432NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539
Abstract
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h
Indexed as
AdultBipolar DisorderBlack or African AmericanCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMajor Depressive DisorderMaleMiddle AgedMultifactorial InheritancePolymorphism, Single NucleotideRisk FactorsSchizophreniaSex Characteristics
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