Evidence map›Paper›PMID 28439080›Full record

ArticleScientific reports2017

ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

Taduru L Sreenath, Shiela S Macalindong, Natallia Mikhalkevich, Shashwat Sharad, Ahmed Mohamed, Denise Young, Talaibek Borbiev, Charles Xavier, Rishita Gupta, Muhammad Jamal and 11 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  5. The non-canonical mechanism of ER stress-mediated progression of prostate cancer.Journal of experimental & clinical cancer research : CR · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Taduru L SreenathCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. tsreenath@cpdr.org.
Shiela S MacalindongCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Natallia MikhalkevichCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Shashwat SharadCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Ahmed MohamedCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Denise YoungCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Talaibek BorbievCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Charles XavierCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Rishita GuptaCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Muhammad JamalCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Kevin BabcockCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Shyh-Han TanCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Marja T NevalainenMCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Albert DobiCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Gyorgy PetrovicsCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Isabell A SesterhennDepartment of Genitourinary Pathology, Joint Pathology Center, Silver Spring, MD, USA.
Inger L RosnerCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Charles J BieberichDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA.
Peter NelsonDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Valeri VasioukhinDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shiv SrivastavaCenter for Prostate Disease Research, USU Walter Reed Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. shiva.srivastava@usuhs.edu.
Uniformed Services University of the Health Sciences · USFred Hutch Cancer Center · USMedical College of Wisconsin · USSeattle University · USUniversity of Maryland, Baltimore County · USWalter Reed National Military Medical Center · US

Funding

Cell Specific Expression Signatures in Prostate Cancer (RO1 DK065977)R01CA162383 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SRIVASTAVA, SHIV · 2011 to 2015
$1.1M
NCI NIH HHS R01 CA162383
6 · The paper itself

Abstract

Mechanistic studies of deregulated ERG in prostate cancer and other cancers continue to enhance its role in cancer biology and its utility as a biomarker and therapeutic target. Here, we show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in the prostate glands of ERG transgenic mice. Histomorphological alterations and the expression of ER stress sensors Atf6, Ire1α, Perk, their downstream effectors Grp78/BiP and eIF2α in ERG transgenic mouse prostate glands indicate the presence of chronic ER stress. Transient activation of apoptotic cell death during early age correlated well with the differential regulation of ER stress sensors, in particular Perk. Epithelial cells derived from ERG transgenic mouse prostates have increased prostasphere formation with resistance to radiation induced cell death. Continued activation of cell survival factors, Atf6 and Ire1α during chronic ER stress due to presence of ERG in prostate epithelium induces survival pathways and provides a selection pressure in the continuum of ERG dependent neoplastic process. These novel insights will enhance the understanding of the mechanistic functions of ERG in prostate tumor biology and towards development of early targeted therapeutic strategies for prostate cancer.

Indexed as

Endoplasmic Reticulum StressProtein Aggregation, PathologicalAnimalsEndoplasmic Reticulum Chaperone BiPGene Expression ProfilingHistocytochemistryImmunohistochemistryMaleMice, TransgenicMicroscopyProstateProstatic NeoplasmsReceptors, AndrogenTranscriptional Regulator ERGEndoplasmic Reticulum Chaperone BiPERG protein, humanHSPA5 protein, humanHspa5 protein, mouseReceptors, AndrogenTranscriptional Regulator ERG

Identifiers

PMID28439080
PMCPMC5430720
OpenAlexW2607445617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.