ArticleScientific reports2017
Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Epidemiology, Species Susceptibility, and Mortality Risk Factors of Pediatric Candidemia: A 13-Year Multicenter Study.Journal of fungi (Basel, Switzerland) · 2026Article
- Neonatal Candida infections in Brazil: study on virulence and antifungal susceptibility with predominance of non-albicans Candida.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Observational
- Article
- Chelerythrine enhances anti-fungi immunity inFrontiers in immunology · 2026Article
- Epidemiology and clinical characterization of invasive fungal infections in pediatric hemato-oncologic patients at a tertiary referral center in Northeastern Mexico.Annals of hematology · 2025Article
- Glucocorticoid use and parenteral nutrition are risk factors for catheter-relatedAsian biomedicine : research, reviews and news · 2024Article
- A 14-Year Cohort of Candidemia in the Pediatric Population in a Tertiary Center in Jerusalem: Clinical Characteristics, Antifungal Susceptibility, and Risk Factors for Mortality.Journal of fungi (Basel, Switzerland) · 2023Article
- InvasiveMicroorganisms · 2023Article
- PediatricJournal of fungi (Basel, Switzerland) · 2022Article
- Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.Nature communications · 2021Article
- Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology.Journal of fungi (Basel, Switzerland) · 2020Article
- Antifungal Activity of Essential Oils Against Candida Species Isolated from Clinical Samples.Mycopathologia · 2019Article
- Invasive candidiasis: Risk factor for mortality in a pediatric tertiary care hospital in south of Brazil.Medicine · 2019Observational
- Risk Factors and Outcomes of Recurrent Candidemia in Children: Relapse or Re-Infection?Journal of clinical medicine · 2019Article
- Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.Scientific reports · 2018Article
- Candidemia due to uncommon Candida species in children: new threat and impacts on outcomes.Scientific reports · 2018Observational
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to determine the clinical and microbiological characteristics of Candida bloodstream infections in children and the impact of therapeutic strategies on outcomes. All pediatric patients with candidemia from a medical center in Taiwan over a 13-year period (2003-2015) were included and a total of 262 patients with 319 episodes of candidemia were analyzed. Overall susceptibility to fluconazole was 86.1%. Cumulative mortality at 7 and 30 days after the first episode of candidemia was 13.4% and 25.2%, respectively. The overall in-hospital mortality rate was 35.1%. The treatment outcomes did not change over the study period. Multivariate analysis showed that delayed catheter removal (odds ratio [OR], 5.52; 95% confidence interval [CI]: 2.97-10.25), septic shock (OR, 5.49; 95% CI: 2.85-10.57), and breakthrough candidemia (OR, 3.66; 95% CI: 1.43-9.35) were independently associated with clinical treatment failure. In children with candidemia, underlying renal insufficiency and hematological/oncological malignancy, delayed catheter removal, and septic shock at onset were independently associated final in-hospital mortality. Analyzing the subgroup of non-neonatal children did not change the findings. We concluded overall mortality of pediatric candidemia remains high during the past decade. Prompt early catheter removal and aggressive treatment strategy in patients with septic shock would be critical to improve outcomes.
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