Evidence map›Paper›PMID 28439040›Full record

ArticleJournal of bacteriology2017

Impact of Membrane Phospholipid Alterations in Escherichia coli on Cellular Function and Bacterial Stress Adaptation.

Veronica W Rowlett, Venkata K P S Mallampalli, Anja Karlstaedt, William Dowhan, Heinrich Taegtmeyer, William Margolin, Heidi Vitrac

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 1 synthesis or guideline pooled it, 277 citations in OpenAlex.

  1. Molecular imaging of bacterial biofilms-a systematic review.Critical reviews in microbiology · 2024
    Pooled it
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  6. Association ofPathogens (Basel, Switzerland) · 2026
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  10. Dark Side ofJournal of the American Chemical Society · 2026
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  14. UsingGut microbes reports · 2026
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  15. Adaptive laboratory evolution ofFrontiers in microbiology · 2026
    Article
  16. Article
  17. Evaluation of thermal desorption-electrospray ionization mass spectrometry for characterization ofJournal of mass spectrometry and advances in the clinical lab · 2025
    Article
  18. Article
  19. Article
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Veronica W RowlettDepartment of Microbiology and Molecular Genetics, University of Texas, McGovern Medical School, Houston, Texas, USA.
Venkata K P S MallampalliDepartment of Biochemistry and Molecular Biology, University of Texas, McGovern Medical School, Houston, Texas, USA.
Anja KarlstaedtDepartment of Internal Medicine, Division of Cardiology, University of Texas, McGovern Medical School, Houston, Texas, USA.
William DowhanDepartment of Biochemistry and Molecular Biology, University of Texas, McGovern Medical School, Houston, Texas, USA.
Heinrich TaegtmeyerDepartment of Internal Medicine, Division of Cardiology, University of Texas, McGovern Medical School, Houston, Texas, USA.
William MargolinDepartment of Microbiology and Molecular Genetics, University of Texas, McGovern Medical School, Houston, Texas, USA.
Heidi VitracDepartment of Biochemistry and Molecular Biology, University of Texas, McGovern Medical School, Houston, Texas, USA heidi.vitrac@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

SWITCHING OF METABOLIC GENES IN UNLOADED HEARTR01HL061483 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TAEGTMEYER, HEINRICH · 1999 to 2021
$6.2M
Targeting and assembly of E. coli division proteinsR01GM061074 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARGOLIN, WILLIAM · 2000 to 2018
$5.7M
Structure and Function in Membrane ProteinsR37GM020478 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 2005 to 2015
$5.4M
STRUCTURE/FUNCTION OF MEMBRANE PROTEINSR01GM020478 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 1985 to 2004
$1.8M
KARYOPHERIN X, A NOVEL TRANSPORT RECEPTORF32GM020478 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLAFKER, SCOTT M · 2000 to 2000
$38k
NHLBI NIH HHS R01 HL061483NIGMS NIH HHS F32 GM020478NIGMS NIH HHS R01 GM020478NIGMS NIH HHS R01 GM061074NIGMS NIH HHS R37 GM020478
6 · The paper itself

Abstract

Bacteria have evolved multiple strategies to sense and rapidly adapt to challenging and ever-changing environmental conditions. The ability to alter membrane lipid composition, a key component of the cellular envelope, is crucial for bacterial survival and adaptation in response to environmental stress. However, the precise roles played by membrane phospholipids in bacterial physiology and stress adaptation are not fully elucidated. The goal of this study was to define the role of membrane phospholipids in adaptation to stress and maintenance of bacterial cell fitness. By using genetically modified strains in which the membrane phospholipid composition can be systematically manipulated, we show that alterations in major

Indexed as

Bacterial AdhesionBacterial Outer Membrane ProteinsBiofilmsCell MembraneEscherichia coliGene Expression Regulation, BacterialHomeostasisLipopolysaccharidesPhospholipidsStress, PhysiologicalBacterial Outer Membrane ProteinsLipopolysaccharidesPhospholipidsmembranesmetabolismphospholipidsphysiologystress adaptationstress response

Identifiers

PMID28439040
PMCPMC5472821
OpenAlexW2609653397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.