Evidence map›Paper›PMID 28438927›Full record

ArticleAntimicrobial agents and chemotherapy2017

Role of

Keiji Murakami, Tsuneko Ono, Darija Viducic, Yoko Somiya, Reiko Kariyama, Kenji Hori, Takashi Amoh, Katsuhiko Hirota, Hiromi Kumon, Matthew R Parsek and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Biofilm · 2024
    Article
  5. Article
  6. Role of Pel and Psl polysaccharides in the response ofMicrobiology (Reading, England) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Clinical Significance of Carbapenem-TolerantAntibiotics (Basel, Switzerland) · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Effects of PslG on the Surface Movement of Pseudomonas aeruginosa.Applied and environmental microbiology · 2018
    Article
  18. Article
  19. Cyclic-di-GMP andFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Keiji MurakamiDepartment of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan kmurakami@tokushima-u.ac.jp.
Tsuneko OnoDepartment of Molecular Microbiology, Institute of Health Biosciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Darija ViducicDepartment of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Yoko SomiyaDepartment of Molecular Microbiology, Institute of Health Biosciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Reiko KariyamaDepartment of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata-cho, Okayama, Japan.
Kenji HoriInnovation Center Okayama for Nanobio-Targeted Therapy, Okayama University, Shikata-cho, Okayama, Japan.
Takashi AmohDepartment of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Katsuhiko HirotaDepartment of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Hiromi KumonDepartment of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata-cho, Okayama, Japan.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Yoichiro MiyakeDepartment of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho, Tokushima, Japan.
Tokushima University · JPOkayama University · JPUniversity of Washington · US

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
NIAID NIH HHS R01 AI077628
6 · The paper itself

Abstract

Bacteria attached to a surface are generally more tolerant to antibiotics than their planktonic counterparts, even without the formation of a biofilm. The mechanism of antibiotic tolerance in biofilm communities is multifactorial, and the genetic background underlying this antibiotic tolerance has not yet been fully elucidated. Using transposon mutagenesis, we isolated a mutant with reduced tolerance to biapenem (relative to that of the wild type) from adherent cells. Sequencing analysis revealed a mutation in the

Indexed as

Anti-Bacterial AgentsBiofilmsCyclic GMPGene Expression Regulation, BacterialOfloxacinOperonPseudomonas aeruginosaAnti-Bacterial AgentsCyclic GMPOfloxacinadherent cellsantibiotic tolerancec-di-GMPPseudomonas aeruginosapsl

Identifiers

PMID28438927
PMCPMC5487641
OpenAlexW2609394499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.