Evidence map›Paper›PMID 28438917›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017

Disease ecology, health and the environment: a framework to account for ecological and socio-economic drivers in the control of neglected tropical diseases.

A Garchitorena, S H Sokolow, B Roche, C N Ngonghala, M Jocque, A Lund, M Barry, E A Mordecai, G C Daily, J H Jones and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  10. Towards a 'people and nature' paradigm for biodiversity and infectious disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

A GarchitorenaDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0001-6225-5226
S H SokolowDepartment of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA.
B RocheUMI UMMISCO 209 IRD/UPMC - Bondy, France.ORCID http://orcid.org/0000-0001-7975-4232
C N NgonghalaDepartment of Mathematics, University of Florida, Gainesville, FL 32611, USA.
M JocqueDepartment of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA.
A LundEmmett Interdisciplinary Program in Environment and Resources, Stanford University, Stanford, CA 94305, USA.
M BarryCenter for Innovation in Global Health, Stanford University, Stanford, CA 94305, USA.
E A MordecaiDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
G C DailyDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
J H JonesDepartment of Earth System Science, Stanford University, Stanford, CA 94305, USA.ORCID http://orcid.org/0000-0003-1680-6757
J R AndrewsDepartment of Medicine, Stanford University, Stanford, CA 94305, USA.
E BendavidDepartment of Medicine, Stanford University, Stanford, CA 94305, USA.
S P LubyCenter for Innovation in Global Health, Stanford University, Stanford, CA 94305, USA.
A D LaBeaudDepartment of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.
K SeetahDepartment of Anthropology, Stanford University, Stanford, CA 94305, USA.
J F GuéganUMR MIVEGEC 5290 CNRS - IRD - Université de Montpellier, Montpellier, France.
M H BondsDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA mhb9@hms.harvard.edu.ORCID http://orcid.org/0000-0002-3055-4237
G A De LeoDepartment of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA.
Stanford University · USPacific University · USBrigham and Women's Hospital · USCenter for Innovation · USCentre National de la Recherche Scientifique · FRImperial College London · GBUniversity of Florida · US

Funding

The child health impacts of overlapping vector-borne diseases in KenyaR01AI102918 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud · 2013 to 2026
$7.7M
Effects of agricultural expansion and intensification on infectionsR01TW010286 · FIC · UNIVERSITY OF SOUTH FLORIDA · PI REMAIS, JUSTIN V, ROHR, JASON ROBERT · 2015 to 2019
$2.4M
The economic impacts of community-based integrated health care systems in rural RK01TW008773 · FIC · HARVARD MEDICAL SCHOOL · PI BONDS, MATTHEW HARRISON · 2010 to 2014
$666k
FIC NIH HHS K01 TW008773FIC NIH HHS R01 TW010286NIAID NIH HHS R01 AI102918
6 · The paper itself

Abstract

Reducing the burden of neglected tropical diseases (NTDs) is one of the key strategic targets advanced by the Sustainable Development Goals. Despite the unprecedented effort deployed for NTD elimination in the past decade, their control, mainly through drug administration, remains particularly challenging: persistent poverty and repeated exposure to pathogens embedded in the environment limit the efficacy of strategies focused exclusively on human treatment or medical care. Here, we present a simple modelling framework to illustrate the relative role of ecological and socio-economic drivers of environmentally transmitted parasites and pathogens. Through the analysis of system dynamics, we show that periodic drug treatments that lead to the elimination of directly transmitted diseases may fail to do so in the case of human pathogens with an environmental reservoir. Control of environmentally transmitted diseases can be more effective when human treatment is complemented with interventions targeting the environmental reservoir of the pathogen. We present mechanisms through which the environment can influence the dynamics of poverty via disease feedbacks. For illustration, we present the case studies of Buruli ulcer and schistosomiasis, two devastating waterborne NTDs for which control is particularly challenging.This article is part of the themed issue 'Conservation, biodiversity and infectious disease: scientific evidence and policy implications'.

Indexed as

Global HealthTropical MedicineConservation of Natural ResourcesEnvironmentHumansNeglected DiseasesPovertycoupled ecological–economic systemsenvironmentally transmitted diseasesplanetary healthsustainable disease control

Identifiers

PMID28438917
PMCPMC5413876
OpenAlexW2609569929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.