Evidence map›Paper›PMID 28438904›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.

Hong Ji, Amrita V Pai, Crystal A West, Xie Wu, Robert C Speth, Kathryn Sandberg

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. Neuroimmune interactions in cardiovascular homeostasis and disease.American journal of physiology. Cell physiology · 2026
    Review
  2. Article
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  5. Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024
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  19. Immunity and Hypertension.Acta physiologica (Oxford, England) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hong JiFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.).
Amrita V PaiFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.).
Crystal A WestFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.).
Xie WuFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.).
Robert C SpethFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.).
Kathryn SandbergFrom the Department of Medicine (H.J., C.A.W., X.W., K.S.), Department of Biochemistry and Molecular and Cell Biology (A.V.P., K.S.), and Center for the Study of Sex Differences in Health, Aging and Disease (H.J., A.V.P., C.A.W., X.W., K.S.), Georgetown University, Washington, DC; and Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL (R.C.S.). sandberg@georgetown.edu.
Georgetown University · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Immune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4M
NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR001409NHLBI NIH HHS R01 HL119380
6 · The paper itself

Abstract

Resistance to angiotensin II (Ang II)-induced hypertension in T-cell-deficient male mice with a targeted mutation in the recombination-activating gene-1 (

Indexed as

Angiotensin IIAnimalsArterial PressureDisease Models, AnimalDrug ResistanceGenes, RAG-1GenotypeHeart RateHypertensionKidney GlomerulusMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicRandom AllocationAngiotensin IIangiotensin IIblood pressuregene deletiongenetic drifthypertensionmicemutation

Identifiers

PMID28438904
PMCPMC5426956
OpenAlexW2893612751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.