Evidence map›Paper›PMID 28438869›Full record

ArticleIn vivo (Athens, Greece)

Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and

Takashi Fukuyama, Nobue Futawatari, Yoshinobu Ichiki, Akiko Shida, Taiga Yamazaki, Yatsushi Nishi, Hiroshi Nonoguchi, Yoshihito Takahashi, Hitoshi Yamazaki, Noritada Kobayashi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Takashi FukuyamaDivision of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan fukuyam@insti.kitasato-u.ac.jp.
Nobue FutawatariDepartment of Surgery, Sagamihara National Hospital, Sagamihara, Japan.
Yoshinobu IchikiSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Akiko ShidaDepartment of Surgery, School of Medicine, Kitasato University, Sagamihara, Japan.
Taiga YamazakiDivision of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan.
Yatsushi NishiDepartment of Surgery, Kitasato University Medical Center, Kitamoto, Japan.
Hiroshi NonoguchiDivision of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan.
Yoshihito TakahashiDepartment of Surgery, School of Medicine, Kitasato University, Sagamihara, Japan.
Hitoshi YamazakiDepartment of Pathology, Kitasato University Medical Center, Kitamoto, Japan.
Noritada KobayashiDivision of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan.
Kitasato University Medical Center · JPKitasato University · JPNational Sagamihara Hospital · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimOur previous study indicated that Kita-kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) expressed in 82% of gastric cancer cases. Here, we investigated the relationship between KK-LC-1 expression and Helicobacter pylori infection in Japanese patients with gastric cancer. PATIENTS AND

methodsWe examined CTA expression in 25 surgical gastric cancer specimens and anti-H. pylori IgGs in the serum of each patient.

resultsKK-LC-1 was expressed in 80% of tumor samples, markedly higher than melanoma antigen gene (MAGE)-A1, MAGE-A3, MAGE-A4, synovial sarcoma, X breakpoint 4 (SSX4) and New York esophageal squamous cell carcinoma-1 (NY-ESO-1). Anti-H. pylori IgG titers from the KK-LC-1-positive patients were significantly higher (67.5±7.6) than those from KK-LC-1-negative patients (15.8±7.5, p<0.01) although there were no significant differences between patients positive and negative for MAGE-A1, -A3 and-A4, SSX4 and NY-ESO-1.

conclusionAs far as we are aware, this is the first report of a correlation between a carcinogen and CTA expression in clinical samples. KK-LC-1 was frequently expressed in gastric cancer caused by H. pylori infection. The risk diagnosis for gastric cancer might be more accurate if KK-LC-1 expression status were also considered.

Indexed as

AdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorFemaleHelicobacter InfectionsHelicobacter pyloriHumansImmunoglobulin GLung NeoplasmsMaleMelanomaMiddle AgedNeoplasm ProteinsPrognosisAntigens, NeoplasmBiomarkers, TumorCT83 protein, humanImmunoglobulin GNeoplasm Proteinscancer/testis antigencarcinogengastric cancerHelicobacter pyloriKK-LC-1

Identifiers

PMID28438869
PMCPMC5461451
OpenAlexW2609301459

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.