Evidence map›Paper›PMID 28438857›Full record

ArticleIn vivo (Athens, Greece)

Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice.

Michael W Epperly, Xichen Zhang, Renee Fisher, Wen Hou, Darcy Franicola, Donna Shields, Michael Quickel, Pamela Hankey-Giblin, Hong Wang, Joel S Greenberger

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michael W EpperlyDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Xichen ZhangDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Renee FisherDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Wen HouDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Darcy FranicolaDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Donna ShieldsDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Michael QuickelDepartment of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA, U.S.A.
Pamela Hankey-GiblinDepartment of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA, U.S.A.
Hong WangDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
Joel S GreenbergerDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A. greenbergerjs@upmc.edu.
UPMC Hillman Cancer Center · USPennsylvania State University · US

Funding

Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4M
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NIAID NIH HHS U19 AI068021
6 · The paper itself

Abstract

BACKGROUND/

aimThe polycythemia form of Friend leukemia virus (FVP) causes splenomegaly and lethal erythroleukemia in Fv-2 MATERIALS AND

methodsThe 120-day bone marrow transplantation competitive repopulation assay was used to determine whether FVP-infected Fv-2

resultsThere was a significant expansion of committed hematopoietic progenitors observed in virus-infected Fv-2

conclusionFriend virus disease in Fv-2

Indexed as

AnimalsBone MarrowFemaleFriend murine leukemia virusHematopoietic Stem CellsLeukemia, Erythroblastic, AcuteLeukemia, ExperimentalMaleMiceMice, Inbred C57BLRetroviridae InfectionsSpleenSplenomegalyTumor Virus Infectionscompetitive repopulation assayFriend virushematopoietic stem cells

Identifiers

PMID28438857
PMCPMC5461439
OpenAlexW2607691292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.