ArticleJournal of neurology, neurosurgery, and psychiatry2017
Psychiatric associations of adult-onset focal dystonia phenotypes.
Article in Journal of neurology, neurosurgery, and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Quality of life in idiopathic dystonia: a systematic review.Journal of neurology · 2019Pooled it
- Pridinol treatment in cervical dystonia: improvement of non-motor symptoms.Annals of medicine · 2026Article
- More than a Movement Disorder: Non-Motor Features and Future Directions in Dystonia Research.Brain sciences · 2025Review
- Association of alcohol responsiveness and non-motor symptoms in isolated adult-onset dystonia.Journal of neurology · 2025Article
- Development of a Patient-Centered Outcome Tool for Blepharospasm: A Stepwise Modified Delphi Study.Toxins · 2025Article
- Non-Motor Symptoms and Health-Related Quality of Life in Patients with Isolated Dystonia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Diagnostic accuracy of screening tools for depression and anxiety in cervical dystonia.Parkinsonism & related disorders · 2025Observational
- Effect of Botulinum toxin on non-motor symptoms in adult-onset idiopathic focal/segmental dystonia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Social determinants of health and health-related quality of life in individuals with isolated dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Longitudinal predictors of health-related quality of life in isolated dystonia.Journal of neurology · 2024Article
- Comparison of Oropharyngeal Dysphagia Before and After Botulinum Toxin Injection in Cervical Dystonia.Dysphagia · 2023Article
- Assessing the Severity of Cervical Dystonia: Ask the Doctor or Ask the Patient?Movement disorders clinical practice · 2023Article
- Non-Motor Symptoms and Quality of Life in Patients with PRRT2-Related Paroxysmal Kinesigenic Dyskinesia.Movement disorders clinical practice · 2023Article
- Development of a New Care Pathway for Depression and Anxiety in Adult-Onset Isolated Dystonia.Movement disorders clinical practice · 2023Article
- Illness Perceptions, Coping, Health-Related Quality of Life and Psychological Outcomes in Cervical Dystonia.Journal of clinical psychology in medical settings · 2023Article
- DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia.Annals of neurology · 2023Article
- A comprehensive cognitive analysis of cervical dystonia: A single centre study.Clinical parkinsonism & related disorders · 2023Article
- DYT-Frontiers in neuroscience · 2023Review
- Anatomical categorization of isolated non-focal dystonia: novel and existing patterns using a data-driven approach.Dystonia (Lausanne, Switzerland) · 2023Article
- Mood symptoms in cervical dystonia: Relationship with motor symptoms and quality of life.Clinical parkinsonism & related disorders · 2023Article
Corrections and comments
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Authors and funding
18 authors at 12 institutions in 4 countries.
Funding
Abstract
backgroundDepression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown.
objectivesThe aim of this study was to determine whether depression, anxiety and social anxiety vary by dystonia onset site and evaluate whether pain and dystonia severity account for any differences.
methodsPatients with isolated focal dystonia evaluated within 5 years from symptom onset, enrolled in the Natural History Project of the Dystonia Coalition, were included in the analysis. Individual onset sites were grouped into five body regions: cervical, laryngeal, limb, lower cranial and upper cranial. Neuropsychiatric symptoms were rated using the Beck Depression Inventory, Hospital Anxiety and Depression Scale and Liebowitz Social Anxiety Scale. Pain was estimated using the 36-Item Short Form Survey.
resultsFour hundred and seventy-eight subjects met our inclusion criteria. High levels of depression, anxiety and social anxiety occurred in all groups; however, the severity of anxiety and social anxiety symptoms varied by onset site group. The most pronounced differences were higher anxiety in cervical and laryngeal, lower anxiety in upper cranial and higher social anxiety in laryngeal. Increases in pain were associated with worse neuropsychiatric symptom scores within all groups. Higher anxiety and social anxiety in laryngeal and lower anxiety in upper cranial persisted after correcting for pain and dystonia severity.
conclusionAnxiety and social anxiety severity vary by onset site of focal dystonia, and this variation is not explained by differences in pain and dystonia severity.
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