Evidence map›Paper›PMID 28438762›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

ET

Megan M Wenner, Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, David G Edwards

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03371823 (Losartan and ET-1 Mediated Constriction in Postmenopausal Women With High Blood Pressure), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03371823 phase4terminatednot on this map

Losartan and ET-1 Mediated Constriction in Postmenopausal Women With High Blood Pressure

TypeinterventionalSponsorUniversity of DelawareRan2017 to 2019Enrolled8ConditionsCardiovascular Diseases, HypertensionArmsNormotensive, Hypertensives
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. ETAmerican journal of physiology. Heart and circulatory physiology · 2021
    Trial
  3. Article
  4. Review
  5. Sodium intake and biological sex influence urinary endothelin-1 in salt-resistant adults: a pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  6. ET(-1) phone home: a commentary on the complexities of cardiovascular disease risk in postmenopausal women.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Characterizing vascular and hormonal changes in women across the life span: a cross-sectional analysis.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Role of BHAmerican journal of physiology. Heart and circulatory physiology · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Megan M WennerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and mwenner@udel.edu.ORCID 0000-0003-0055-783X
Kelly N SebzdaDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and.
Andrew V KuczmarskiDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and.
Ryan T PohligBiostatistics Core Facility, College of Health Sciences, University of Delaware, Newark, Delaware.
David G EdwardsDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and.
University of Delaware · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM113125NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

Endothelin-1 (ET-1) contributes to age-related endothelial dysfunction in men via the ET

Indexed as

VasodilationAgingFemaleGene Expression RegulationHumansMiddle AgedPostmenopauseReceptor, Endothelin BYoung AdultEDNRB protein, humanReceptor, Endothelin Bagingcutaneous circulationendothelial functionendothelin-1

Identifiers

PMID28438762
PMCPMC5538850
OpenAlexW2608004827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.