Evidence map›Paper›PMID 28438678›Full record

ReviewVision research2017

Do photoreceptor cells cause the development of retinal vascular disease?

Timothy S Kern

Abstract readReview
In one paragraph

Review in Vision research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Rod photoreceptor activation and deactivation in early-stage diabetic eye disease.Documenta ophthalmologica. Advances in ophthalmology · 2023
    Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Timothy S KernDepartments of Pharmacology, Medicine, Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, United States; Veterans Administration Medical Center Research Service 151, Cleveland, OH 44106, United States. Electronic address: tsk@case.edu.

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
STUDY OF DIABETIC RETINOPATHYR01EY000300 · NEI · UNIVERSITY OF WISCONSIN MADISON · PI KERN, TIMOTHY S · 1985 to 2013
$4.7M
Role of Photoreceptors in the Pathogenesis of Diabetic RetinopathyR01EY022938 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2013 to 2021
$3.7M
Study of diabetic retinopathyR56EY000300 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI KERN, TIMOTHY S · 2009 to 2009
$353k
BLR&D Research Career Scientist ApplicationIK6BX003604 · VA · VETERANS HEALTH ADMINISTRATION · PI KERN, TIMOTHY S · 2017 to 2021
–
BLRD VA IK6 BX003604NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY000300NEI NIH HHS R01 EY022938NEI NIH HHS R24 EY024864NEI NIH HHS R56 EY000300
6 · The paper itself

Abstract

The retinal vasculature is affected in a number of clinically important retinopathies, including diabetic retinopathy. There has been a considerable amount of research into the pathogenesis of retinal microvascular diseases, but the potential contribution of the most abundant cell population in the retina, photoreceptor cells, has been largely overlooked. This review summarizes ongoing research suggesting that photoreceptor cells play a critical role in the development of retinal vascular disease in diabetic retinopathy and other retinopathies.

Indexed as

AnimalsDiabetic RetinopathyHumansPhotoreceptor Cells, VertebrateRetinal VesselsMicrovasculatureOpsinPhotoreceptorsRetina

Identifiers

PMID28438678
PMCPMC5677572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.