Evidence map›Paper›PMID 28438184›Full record

ArticleMicrobiome2017

Microbiota-activated CD103

Chris Fleming, Yihua Cai, Xuan Sun, Venkatakrishna R Jala, Feng Xue, Samantha Morrissey, Yu-Ling Wei, Yueh-Hsiu Chien, Huang-Ge Zhang, Bodduluri Haribabu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. γδ T cells in oral diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Pooled it
  2. Article
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  10. Exhausted intratumoral Vδ2Nature immunology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Chris FlemingDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA.
Yihua CaiDepartment of Medicine, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Xuan SunDepartment of Medicine, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Venkatakrishna R JalaDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA.
Feng XueDepartment of Medicine, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Samantha MorrisseyDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA.
Yu-Ling WeiDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Yueh-Hsiu ChienDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Huang-Ge ZhangDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA.
Bodduluri HaribabuDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA.
Jian HuangDepartment of Oncology, Zhejiang University the Second Affiliated Hospital, Hangzhou, China.
Jun YanDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA. jun.yan@louisville.edu.
University of Louisville · USStanford University · USSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIL-17-producing γδT cells (γδT17) promote autoinflammatory diseases and cancers. Yet, γδT17 peripheral regulation has not been thoroughly explored especially in the context of microbiota-host interaction. The potent antigen-presenting CD103

methodsImmunophenotyping of IL-17r

resultsWe found drastic homeostatic expansion of γδT17 in all major tissues, most prominently in cervical lymph nodes (cLNs) with monoclonal expansion of Vγ6 γδT17 in IL-17r

conclusionsThese findings reveal for the first time that γδT17 cells are regulated by microbiota dysbiosis through cell-to-cell contact with activated CD103

Indexed as

AnimalsAntigens, CDBacteriaDendritic CellsDNA, BacterialDNA, RibosomalGastrointestinal MicrobiomeIntegrin alpha ChainsMiceMice, KnockoutMicrobiotaMouthPhylogenyReceptors, Interleukin-17RNA, Ribosomal, 16SSequence Analysis, DNAalpha E integrinsAntigens, CDDNA, BacterialDNA, RibosomalIl17ra protein, mouseIntegrin alpha ChainsReceptors, Interleukin-17RNA, Ribosomal, 16SDendritic cellsFecal transplantGamma delta T cellsGerm-freeGutHost-microbiota interactionIL-17MicrobiomeMicrobiotaMicrobiota transferOral

Identifiers

PMID28438184
PMCPMC5404689
OpenAlexW2513746620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.