ArticleBMC genomics2017
Genome adaptive evolution of Lactobacillus casei under long-term antibiotic selection pressures.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
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- ProcaryaSV: structural variation detection pipeline for bacterial genomes using short-read sequencing.BMC bioinformatics · 2024Article
- Evidence ofMicrobial genomics · 2024Article
- Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut.NPJ biofilms and microbiomes · 2023Article
- Development of Thermotolerant Lactobacilli Cultures with Improved Probiotic Properties Using Adaptive Laboratory Evolution Method.Probiotics and antimicrobial proteins · 2023Article
- Vaginal microbiota of adolescents and their mothers: A preliminary study of vertical transmission and persistence.Frontiers in microbiomes · 2023Article
- Gut microbiome and aging nexus and underlying mechanism.Applied microbiology and biotechnology · 2022Review
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- DietaryExperimental and therapeutic medicine · 2021Article
- How industrial bacterial cultures can be kept stable over time.Letters in applied microbiology · 2020Review
- Complete Genomic Analysis ofFrontiers in bioengineering and biotechnology · 2020Article
- Laboratory Evolution Assays and Whole-Genome Sequencing for the Development and Safety Evaluation ofFrontiers in microbiology · 2019Article
- Characterization of the Adaptive Amoxicillin Resistance ofFrontiers in microbiology · 2018Article
- Adaptation ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extensive use of antibiotics in medicine has raised serious concerns about biosafety. However, the effect of antibiotic application on the adaptive evolution of microorganisms, especially to probiotic bacteria, has not been well characterized. Thus, the objective of the current work was to investigate how antibiotic selection forces might drive genome adaptation using Lactobacillus (L.) casei Zhang as a model.
methodsTwo antibiotics, amoxicillin and gentamicin, were consistently applied to the laboratory culture of L. casei Zhang. We then monitored the mutations in the bacterial genome and changes in the minimum inhibitory concentrations (MICs) of these two antibiotics along a 2000-generation-cultivation lasted over 10 months.
resultsWe found an approximately 4-fold increase in the genome mutation frequency of L. casei Zhang, i.e. 3.5 × 10
conclusionsOur study has shown that the probiotic species, L. casei Zhang, has high genome stability even in the presence of long-term antibiotic stresses. However, whether this is a species-specific or universal characteristic for all probiotic bacteria remains to be explored.
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