ArticleBMC infectious diseases2017
Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- BreathERJ open research · 2025Article
- Machine Learning for Prediction of Tuberculosis Detection: Case Study of Trained African Giant Pouched Rats.Online journal of public health informatics · 2024Article
- Scent detection of Brucella abortus by African giant pouched rats (Cricetomys ansorgei).BMC veterinary research · 2023Article
- Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics.Micromachines · 2023Review
- Breath can discriminate tuberculosis from other lower respiratory illness in children.Scientific reports · 2021Article
- Visual Analytics of Tuberculosis Detection Rat Performance.Online journal of public health informatics · 2021Article
- The Many Hosts of Mycobacteria 8 (MHM8): A conference report.Tuberculosis (Edinburgh, Scotland) · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfrican pouched rats sniffing sputum samples provided by local clinics have significantly increased tuberculosis case findings in Tanzania and Mozambique. The objective of this study was to determine the reproducibility of rat results.
methodsOver an 18-month period 11,869 samples were examined by the rats. Intra-rater reliability was assessed through Yule's Q. Inter-rater reliability was assessed with Krippendorff's alpha.
resultsIntra-rater reliability was high, with a mean Yule's Q of 0.9. Inter-rater agreement was fair, with Krippendorf's alpha ranging from 0.15 to 0.45. Both Intra- and Inter-rater reliability was independent of the sex of the animals, but they were positively correlated with age. Both intra- and inter-rater agreement was lowest for samples designated as smear-negative by the clinics.
conclusionOverall, the reproducibility of tuberculosis detection rat results was fair and diagnostic results were therefore independent of the rats used.
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