ArticleBritish journal of pharmacology2017
Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
- Sodium-Glucose Transporter-2 Inhibitors (SGLT2i) and Myocardial Ischemia: Another Compelling Reason to Consider These Agents Regardless of Diabetes.International journal of molecular sciences · 2025Review
- Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Dietary Beetroot Juice - Effects in Patients with COPD: A Review.International journal of chronic obstructive pulmonary disease · 2024Review
- Associations Between Hourly Ambient Particulate Matter Air Pollution and Ambulance Emergency Calls: Time-Stratified Case-Crossover Study.JMIR public health and surveillance · 2023Article
- Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation.Particle and fibre toxicology · 2022Article
- The Acute Effect of Diesel Exhaust Particles and Different Fractions Exposure on Blood Coagulation Function in Mice.International journal of environmental research and public health · 2021Article
- Platelet Effects of Anti-diabetic Therapies: New Perspectives in the Management of Patients with Diabetes and Cardiovascular Disease.Frontiers in pharmacology · 2021Review
- L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221.BioMed research international · 2020Article
- Ambient air pollution and thrombosis.Particle and fibre toxicology · 2018Review
- Refinement of a mouse cardiovascular model: Development, application and dissemination.F1000Research · 2018Review
- Response to 'Effects of diesel exhaust particles on coagulation'.British journal of pharmacology · 2017Article
- Effects of diesel exhaust particles on coagulation.British journal of pharmacology · 2017Article
- Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways.British journal of pharmacology · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeExposure to nanoparticulate pollution has been implicated in platelet-driven thrombotic events such as myocardial infarction. Inflammation and impairment of NO bioavailability have been proposed as potential causative mechanisms. It is unclear, however, whether airways exposure to combustion-derived nanoparticles such as diesel exhaust particles (DEP) or carbon black (CB) can augment platelet aggregation in vivo and the underlying mechanisms remain undefined. We aimed to investigate the effects of acute lung exposure to DEP and CB on platelet activation and the associated role of inflammation and endothelial-derived NO. EXPERIMENTAL APPROACH: DEP and CB were intratracheally instilled into wild-type (WT) and eNOS KEY
resultsPlatelet aggregation in vivo was significantly enhanced in WT and eNOS CONCLUSIONS AND IMPLICATIONS: Pulmonary exposure to DEP and subsequent platelet activation may contribute to the reports of increased cardiovascular risk, associated with exposure to airborne pollution, independent of its effects on inflammation or NO bioavailability.
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