Evidence map›Paper›PMID 28437680›Full record

Trial reportBehaviour research and therapy2017

How durable is the effect of low intensity CBT for depression and anxiety? Remission and relapse in a longitudinal cohort study.

Shehzad Ali, Laura Rhodes, Omar Moreea, Dean McMillan, Simon Gilbody, Chris Leach, Mike Lucock, Wolfgang Lutz, Jaime Delgadillo

2 registry-linked trialsAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Behaviour research and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04811521 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room

TypeinterventionalSponsorIndiana UniversityRan2021 to 2025Enrolled375ConditionsGeneralized Anxiety Disorder, Chest Pain, PanicArmsPrimary care follow-up, Online Self-Administered Anxiety Management Program plus Peer Support Guidance, Therapist-Administered Cognitive Behavioral Therapy
NCT06091163 nacompletednot on this mapstarted 2024, after this paper: background citation

A Randomised Controlled Trial Evaluating the Efficacy and Mechanisms of a Ketogenic Diet as an Adjunctive Treatment for People With Treatment-resistant Depression

TypeinterventionalSponsorUniversity of OxfordRan2024 to 2024Enrolled88ConditionsTreatment Resistant Depression, Depression, Mental Illness, Mental DisorderArmsKetogenic Diet, Phytonutrient Diet
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 140 citations in OpenAlex.

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  14. A randomized controlled trial of a smartphone-based application for the treatment of anxiety.Psychotherapy research : journal of the Society for Psychotherapy Research · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Shehzad AliDepartment of Health Sciences and Centre for Health Economics, University of York, York, UK.
Laura RhodesLeeds Community Healthcare NHS Trust, Leeds, UK.
Omar MoreeaCentre for Clinical Practice, National Institute for Health and Care Excellence, Manchester, UK.
Dean McMillanHull York Medical School and Department of Health Sciences, University of York, York, United Kingdom.
Simon GilbodyHull York Medical School and Department of Health Sciences, University of York, York, United Kingdom.
Chris LeachSouth West Yorkshire Partnership NHS Foundation Trust and University of Huddersfield, Huddersfield, UK.
Mike LucockSouth West Yorkshire Partnership NHS Foundation Trust and University of Huddersfield, Huddersfield, UK.
Wolfgang LutzDepartment of Psychology, University of Trier, Trier, Germany.
Jaime DelgadilloClinical Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK. Electronic address: jaime.delgadillo@nhs.net.
University of Huddersfield · GBUniversity of York · GBHull York Medical School · GBLeeds Community Healthcare NHS Trust · GBNational Institute for Health and Care Excellence · GBUniversität Trier · DEUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression and anxiety disorders are relapse-prone conditions, even after successful treatment with pharmacotherapy or psychotherapy. Cognitive behavioural therapy (CBT) is known to prevent relapse, but there is little evidence of the durability of remission after low intensity forms of CBT (LiCBT).

methodThis study aimed to examine relapse rates 12 months after completing routinely-delivered LiCBT. A cohort of 439 LiCBT completers with remission of symptoms provided monthly depression (PHQ-9) and anxiety (GAD-7) measures during 12 months after treatment. Survival analysis was conducted to model time-to-relapse while controlling for patient characteristics.

resultsOverall, 53% of cases relapsed within 1 year. Of these relapse events, the majority (79%) occurred within the first 6 months post-treatment. Cases reporting residual depression symptoms (PHQ-9 = 5 to 9) at the end of treatment had significantly higher risk of relapse (hazard ratio = 1.90, p < 0.001).

conclusionsThe high rate of relapse after LiCBT highlights the need for relapse prevention, particularly for those with residual depression symptoms.

Indexed as

Cognitive Behavioral TherapyAdolescentAdultAgedAged, 80 and overAnxietyDepressionFemaleHumansLongitudinal StudiesMaleMiddle AgedRecurrenceRemission InductionTime FactorsYoung AdultAnxietyCognitive behavioural therapyDepressionRelapse

Identifiers

PMID28437680
OpenAlexW2605428381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.