ArticleJournal of surgical oncology2017
Modified frailty index predicts postoperative outcomes in older gastrointestinal cancer patients.
Article in Journal of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03568110 (The Impact of Frailty on the Postoperative Outcomes of Gastric Cancer Surgery), which is not on this map. Cited by 47 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Frailty on the Postoperative Outcomes of Gastric Cancer Surgery
Who cites it
47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Frailty as a predictor of postoperative outcomes in older gastroesophageal cancer patients: a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Preoperative frailty and postoperative complications after non-cardiac surgery: a systematic review.The Journal of international medical research · 2024Pooled it
- Risk factors for preoperative frailty in older patients with gastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Prevalence and unfavorable outcome of frailty in older adults with gastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- The Association of Frailty with Outcomes after Cancer Surgery: A Systematic Review and Metaanalysis.Annals of surgical oncology · 2022Pooled it
- Frailty and risk of complications in head and neck oncologic surgery. Systematic review and dose-response meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Impact of frailty on outcomes in surgical patients: A systematic review and meta-analysis.American journal of surgery · 2019Pooled it
- Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial.Geriatrics & gerontology international · 2025Trial
- Preoperative Laboratory, Imaging, and Risk Assessment Before Elective Colorectal Cancer Resection: What the Clinician Must Remember.Journal of clinical medicine · 2026Review
- Does age have an impact on surgical and oncologic outcomes after curative resection for gastric cancer: a ten-year single-centre retrospective study.Radiology and oncology · 2026Article
- Postoperative frailty among elderly patients undergoing radical surgery for gastrointestinal tumors and its relationship with prognosis.Journal of gastrointestinal oncology · 2026Article
- Predictive performance of the Modified Frailty Index and ASA-PS classification for 30-day mortality after esophagectomy in patients with esophageal cancer.Frontiers in oncology · 2026Article
- Hypothetical Interventions on Frailty Heterogeneous Trajectories of Older Patients with Gastric Cancer Using Parametric G-Formula.Annals of surgical oncology · 2025Observational
- Association Between Preoperative Frailty Using Frailty Index-Laboratory Test and Clinical Outcomes in Older Adults Undergoing Brain Tumor Surgery.Nursing & health sciences · 2025Article
- Association of frailty and its trajectory with the risk of cancer: evidence from the China health and retirement longitudinal study (CHARLS).BMC public health · 2025Article
- Frailty predicts adverse clinical outcomes in patients with moderate to severe chronic kidney disease.Aging · 2025Article
- Survival Analysis of 4 Different Age Groups of Pancreatic Ductal Adenocarcinoma After Radical Resection From Retrospective Multi-Center Analysis (YPB-003).Cancer medicine · 2025Article
- Impact of a minimally invasive approach for colon cancer surgery on outcomes in patients with functional limitations.Colorectal cancer · 2025Article
- Comparison of Modified Frailty Index, Clinical Frailty Scale, ECOG Score, and ASA PS Score in Predicting Postoperative Outcomes in Cancer Surgery: A Prospective Study.Indian journal of surgical oncology · 2024Article
- Effect of Frailty on Postoperative Outcomes Following Major Abdominal Surgeries: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesFrailty disproportionately impacts older patients with gastrointestinal cancer, rendering them at increased risk for poor outcomes. A frailty index may aid in preoperative risk stratification. We hypothesized that high modified frailty index (mFI) scores are associated with adverse outcomes after tumor resection in older, gastrointestinal cancer patients.
methodsPatients (60-90 years old) who underwent gastrointestinal tumor resection were identified in the 2005-2012 NSQIP Participant Use File. mFI was defined by 11 previously described, preoperative variables. Frailty was defined by an mFI score >0.27. The postoperative course was evaluated using univariate and multivariate analysis.
results41 455 patients (mean age 72.4 years, 47.4% female) were identified. The most prevalent form of cancer was colorectal (69.3%, n = 28 708) and 2.8% of patients were frail (n = 1,164). Frail patients were significantly more likely to have increased length of stay (11.7 vs 9.0 days), major complications (29.1% vs 17.9%), and 30-day mortality (5.6% vs 2.5%), (all P < 0.001). Multivariate analysis identified mFI as an independent predictor of major complications (OR 1.52, 95%CI 1.39-1.65, P < 0.001) and 30-day mortality (OR 1.48, 95%CI 1.24-1.75, P < 0.001).
conclusionsmFI was associated with the incidence of postoperative complications and mortality in older surgical patients with gastrointestinal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.