Evidence map›Paper›PMID 28437188›Full record

ArticleRadiation research2017

Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding.

Joseph R Dynlacht, Joy Garrett, Rebecca Joel, Katharina Lane, Marc S Mendonca, Christie M Orschell

Abstract read
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Cell Therapies for Acute Radiation Syndrome.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Combined injury: irradiation with skin or bone wounds in rodent models.Journal of radiological protection : official journal of the Society for Radiological Protection · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph R Dynlachta   Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Joy Garretta   Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Rebecca Joela   Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Katharina Lanea   Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Marc S Mendoncaa   Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Christie M Orschellb   Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

The Development of Thermally-activated Metalloenediynes for Cancer TherapyR01CA196293 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI DYNLACHT, JOSEPH R, ZALESKI, JEFFREY M · 2015 to 2019
$2.4M
Initial characterization of a non-pharmacological radiation countermeasureR21ES021631 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI DYNLACHT, JOSEPH R · 2012 to 2013
$425k
NCI NIH HHS R01 CA196293NIEHS NIH HHS R21 ES021631
6 · The paper itself

Abstract

There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD

Indexed as

Survival RateAcute Radiation SyndromeAnimalsFemaleHematopoiesisMaleMiceMice, Inbred C57BLPuncturesRadiation DosageSurgical WoundTreatment OutcomeWhole-Body Irradiation

Identifiers

PMID28437188
PMCPMC5526636
OpenAlexW2609274313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.