ArticleJournal of athletic training2017
Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space.
Article in Journal of athletic training, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Corticospinal tract alterations after ankle sprain in adolescence: Insights from the mouse model.Sports medicine and health science · 2025Article
- Ligamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model.BMC musculoskeletal disorders · 2022Article
- Decreased perceived ankle and knee joint health in individuals with perceived chronic ankle instability.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Osteoarthritis Prevalence in Retired National Football League Players With a History of Ankle Injuries and Surgery.Journal of athletic training · 2019Article
- Prolonged Rest, Long-Term Dynamic Balance, and Gait in a Mouse Ankle-Sprain Model.Journal of athletic training · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAnkle sprains remain the most common orthopaedic injury. Conducting long-term studies in humans is difficult and costly, so the long-term consequences of an ankle sprain are not entirely known.
objectiveTo measure knee-joint space after a single surgically induced ankle sprain in mice.
designRandomized controlled trial.
settingUniversity research laboratory. PATIENTS OR OTHER
participantsThirty male mice (CBA/2J) were randomly placed into 1 of 3 surgical groups: the transected calcaneofibular ligament (CFL) group, the transected anterior talofibular ligament/CFL group, or a sham treatment group. The right ankle was operated on in all mice. MAIN OUTCOME MEASURE(S): Three days after surgery, all of the mice were individually housed in cages containing a solid-surface running wheel, and daily running-wheel measurements were recorded. Before surgery and every 6 weeks after surgery, a diagnostic ultrasound was used to measure medial and lateral knee-joint space in both hind limbs.
resultsRight medial (P = .003), right lateral (P = .002), left medial (P = .03), and left lateral (P = .002) knee-joint spaces decreased across the life span. The mice in the anterior talofibular ligament/CFL group had decreased right medial (P = .004) joint space compared with the sham and CFL groups starting at 24 weeks of age and continuing throughout the life span. No differences occurred in contralateral knee-joint degeneration among any of the groups.
conclusionsBased on current data, mice that sustained a surgically induced severe ankle sprain developed greater joint degeneration in the ipsilateral knee. Knee degeneration could result from accommodation to the laxity of the ankle or biomechanical alterations secondary to ankle instability. A single surgically induced ankle sprain could significantly affect knee-joint function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.