Evidence map›Paper›PMID 28436978›Full record

Trial reportBone marrow transplantation2017

Association of hematopoietic cell transplantation-specific comorbidity index with resource utilization after allogeneic transplantation.

L Decook, Y-H Chang, J Slack, D Gastineau, J Leis, P Noel, J Palmer, L Sproat, M Sorror, N Khera

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

L DecookDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Y-H ChangDepartment of Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, USA.
J SlackDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
D GastineauDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
J LeisDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
P NoelDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
J PalmerDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
L SproatDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
M SorrorClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
N KheraDepartment of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comorbidities affect clinical outcomes and costs in medicine. The hematopoietic cell transplantation (HCT)-specific comorbidity index (HCT-CI) predicts mortality risk after HCT. Its association with resource utilization (RU) is unknown. In this single-center, retrospective study, we examined the association of HCT-CI with RU (readmissions, length of hospital stay (LOS) and days out of hospital alive (DOHA)) in first 100 days (n=328) and 1 year (n=226) in allogeneic HCT patients from January 2010 to June 2014. Age, disease risk, conditioning and use of antithymocyte globulin were significantly different in the four groups with HCT-CI 0 to1 (n=138), 2 (n=56), 3 (n=55) or ⩾4 (n=79). Although the readmissions were higher in the first 100 days for patients with HCT-CI >0-1 (P=0.03), they were not significantly different in patients over 1 year (P=0.13). In the multivariable analysis, patients with HCT-CI score of >0 to 1 had increased LOS and fewer DOHA in both 100 days and 1 year after HCT. In this exploratory analysis, we found that HCT-CI >0 to 1 is associated with increased RU after allogeneic HCT. Recognizing predictors of RU can identify patients at risk of high utilization and help understand what drives health-care costs.

Indexed as

ComorbidityHematopoietic Stem Cell TransplantationPatient ReadmissionAdolescentAdultAgedAllograftsFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID28436978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.