ArticleScientific reports2017
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
377 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The impact of microplastics on the mice gut microbiome: a meta-analysis.Scientific reports · 2026Pooled it
- Global research trends and mechanistic pathways linking micro- and nano plastics exposure to metabolic health: a bibliometric and evidence-mapping analysis (2013-2025).Frontiers in nutrition · 2026Pooled it
- A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.Particle and fibre toxicology · 2025Pooled it
- Mapping Microplastics in Humans: Analysis of Polymer Types, and Shapes in Food and Drinking Water-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Occurrence, transport, and toxicity of microplastics in tropical food chains: perspectives view and way forward.Environmental geochemistry and health · 2024Pooled it
- Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial.Nature communications · 2026Trial
- Bridging environmental pollution and immune dysregulation: How microplastics disrupt gut homeostasis to promote allergic diseases.Virulence · 2026Review
- Colonic Barrier Dysfunction and Inflammation Induced by Nano-/Micro-Plastics Fibers in Mice via the FAK/NF-κB/iNOS and TLR4/NF-κB/iNOS Pathways.Journal of applied toxicology : JAT · 2026Article
- Polystyrene Microplastics Induce Nephrotoxicity via Oxidative Stress, Inflammation, Autophagy, and Ferroptosis.Journal of applied toxicology : JAT · 2026Review
- Engineered and Weathered Polyethylene Terephthalate (PET) Microplastics and Nanoplastics Induce Form and Size-Dependent Oxidative Stress, Oxidative DNA Damage, and Cytotoxicity in MCF-7 Cells.Environmental toxicology · 2026Article
- Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism.Nature metabolism · 2026Article
- Environmentally relevant aged nanoplastics amplify oxidative stress-associated inhalation toxicity and delay lung clearance.Redox biology · 2026Article
- Investigating the Release and Toxicity of Microplastics/Nanoplastics From Single-Use Plastic Bags to Zebrafish.Journal of applied toxicology : JAT · 2026Article
- Dose-Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats.Journal of applied toxicology : JAT · 2026Article
- Association between Microplastic Exposure and Hepatic Dysfunction in Humans: A Cross-Sectional Study of Occupationally Exposed Individuals.Environment & health (Washington, D.C.) · 2026Article
- Effects of microplastics and nanoplastics on the kidneys.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Dietary Microplastic Exposure in Athletes: Implications for Metabolism, Gut Health, and Performance.Nutrients · 2026Review
- 4-Phenylbutyric acid attenuates endoplasmic reticulum stress-mediated polystyrene microplastic-induced nephrotoxicity in Wistar rats.Molecular biology reports · 2026Article
- Gut and Glomerular Barriers Determine Nanoplastic Fate and Systemic Impact.ACS environmental Au · 2026Article
- Article
317 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.