ArticleScientific reports2017
The Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4-trauma, burn, obstetrics, acute pancreatitis/liver failure, and others.International journal of hematology · 2025Guideline
- Management of Hereditary Hypofibrinogenemia During Pregnancy: A Scoping Review Towards Personalized Obstetric Care.Journal of clinical medicine · 2026Review
- Recommendations for implementing patient blood management-an updated modified Delphi consensus from a multidisciplinary expert panel in Hong Kong.Journal of anesthesia, analgesia and critical care · 2026Review
- The Role of Systemic Inflammatory Indices in Predicting Composite Adverse Outcomes of Peripartum Hemorrhage Treated with Fibrinogen Concentrate.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Effective use of fibrinogen concentrate in a pediatric splenic injury requiring transcatheter arterial embolization.Trauma case reports · 2024Article
- Article
- Changes in use and outcomes after fibrinogen concentrate insurance coverage for critical obstetrical hemorrhage: a nationwide questionnaire survey in Japan.Scientific reports · 2024Article
- Comparative analysis of hyperfibrinolysis with activated coagulation between amniotic fluid embolism and severe placental abruption.Scientific reports · 2024Article
- Clinical experience of the use of fibrinogen concentrate for massive postpartum hemorrhage: a retrospective case series study.Journal of anesthesia · 2023Article
- Placental abruption at near-term and term gestations: pathophysiology, epidemiology, diagnosis, and management.American journal of obstetrics and gynecology · 2023Review
- Review of Current Insights and Therapeutic Approaches for the Treatment of Refractory Postpartum Hemorrhage.International journal of women's health · 2023Review
- Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study.Scientific reports · 2021Article
- Effect of hypofibrinogenemia on obstetrical disseminated intravascular coagulation in Japan in 2018: a multicenter retrospective cohort study.International journal of hematology · 2021Article
- Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease.Seminars in hematology · 2020Review
- Management of disseminated intravascular coagulation associated with placental abruption and measures to improve outcomes.Obstetrics & gynecology science · 2019Review
- Postpartum hemorrhage: Blood product management and massive transfusion.Seminars in perinatology · 2019Review
- Fibrinogen for the management of critical obstetric hemorrhage.The journal of obstetrics and gynaecology research · 2019Review
- Early fibrinogen replacement based on shock index and lactate levels in massive postpartum hemorrhage: a retrospective cohort study.Blood transfusion = Trasfusione del sangueArticle
- Use of Fresh-frozen Plasma in Newborn Infants.Newborn (Clarksville, Md.)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. We compared the efficacy of FFP (F group) with that of FFP plus fibrinogen concentrate (F + F group) in massive obstetric haemorrhage. In this retrospective study, we compared the medical charts (2004-2016) of 137 patients with <150 mg/dl fibrinogen treated with F + F (n = 47; after August 2009) or F (n = 56; before August 2009). Although fibrinogen concentrate was only administered in severe cases, the FFP/red blood cell concentrate (RCC) ratio was significantly lower in the F + F group than in the F group. A sub-group analysis of cases requiring ≥18 RCC units showed that the F + F group received significantly less FFP than the F group (40.2 ± 19.6 versus 53.4 ± 18.5 units; P = 0.047) and showed significantly less pulmonary oedema (24.0% vs 57.1%; P < 0.05) in the absence of any significant differences in pre-transfusion coagulation, estimated blood loss, or RCC transfusion volume. Administration of fibrinogen concentrate increased the rate of fibrinogen supplementation five-fold and reduced FFP dosage, the FFP/RCC ratio, and the incidence of pulmonary oedema.
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