ArticlePsychological medicine2017
Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 7 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses.Molecular psychiatry · 2026Pooled it
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Pooled it
- A Systematic Review of the Positive Valence System in Autism Spectrum Disorder.Neuropsychology review · 2021Pooled it
- The functional neural architecture of dysfunctional reward processing in autism.NeuroImage. Clinical · 2021Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Evaluation of the Social Motivation Hypothesis of Autism: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants.Scientific reports · 2021Trial
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- Autism-related proteins form a complex to maintain the striatal asymmetry in mice.Cell research · 2025Article
- Early identification of autism spectrum disorder in preschoolers by static and dynamic amplitude of low-frequency fluctuations features.Frontiers in human neuroscience · 2025Article
- Association of temporal discounting with transdiagnostic symptom dimensions.Npj mental health research · 2024Article
- Chronic Deep Brain Stimulation of the Human Nucleus Accumbens Region Disrupts the Stability of Intertemporal Preferences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder.Frontiers in psychiatry · 2023Review
- Motivation from Agency and Reward in Typical Development and Autism: Narrative Review of Behavioral and Neural Evidence.Brain sciences · 2022Review
- Contagion of Temporal Discounting Value Preferences in Neurotypical and Autistic Adults.Journal of autism and developmental disorders · 2022Article
- Functional Connectivity Underlying Symptoms in Preschool Boys With Autism: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- On the Development of OCD.Current topics in behavioral neurosciences · 2021Review
- Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders.Frontiers in neuroscience · 2021Article
- Striatal bases of temporal discounting in early adolescents.Neuropsychologia · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.
methodsAge and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.
resultsBoys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.
conclusionsThis first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.