ArticleJournal of applied clinical medical physics2017
A complete 4DCT-ventilation functional avoidance virtual trial: Developing strategies for prospective clinical trials.
Article in Journal of applied clinical medical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Incorporation of Functional Lung Imaging Into Radiation Therapy Planning in Patients With Lung Cancer: A Systematic Review and Meta-Analysis.International journal of radiation oncology, biology, physics · 2024Pooled it
- Patient-Reported Outcomes: Comparing Functional Avoidance and Standard Thoracic Radiation Therapy in Lung Cancer.JCO clinical cancer informatics · 2025Trial
- Prospective Trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report.International journal of radiation oncology, biology, physics · 2024Trial
- Evaluation of variables predicting PFT changes for lung cancer patients treated on a prospective 4DCT-ventilation functional avoidance clinical trial.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Trial
- Results of a Multi-Institutional Phase 2 Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiation Therapy.International journal of radiation oncology, biology, physics · 2022Trial
- Interim Analysis of a Two-Institution, Prospective Clinical Trial of 4DCT-Ventilation-based Functional Avoidance Radiation Therapy.International journal of radiation oncology, biology, physics · 2018Trial
- Functional lung avoidance proton radiation therapy planning using anatomy-wise computed tomography-derived lung ventilation imaging.Radiation oncology (London, England) · 2026Article
- Integrating spot-scanning proton arc therapy with functional avoidance strategies to reduce pulmonary toxicity.Physics and imaging in radiation oncology · 2025Article
- Comprehensive clinical evaluation of novel 4DCT-based lung function imaging methods.Journal of applied clinical medical physics · 2025Article
- A review on functional lung avoidance radiotherapy plan for lung cancer.Frontiers in oncology · 2024Review
- Advances in CT-based lung function imaging for thoracic radiotherapy.Frontiers in oncology · 2024Review
- Functional lung avoidance in radiotherapy using optimisation of biologically effective dose with non-coplanar beam orientations.Physics and imaging in radiation oncology · 2023Article
- Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer.Frontiers in oncology · 2022Article
- A Transfer Learning Framework for Deep Learning-Based CT-to-Perfusion Mapping on Lung Cancer Patients.Frontiers in oncology · 2022Article
- Radiation-induced lung injury - what do we know in the era of modern radiotherapy?Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Review
- Functional lung imaging in thoracic tumor radiotherapy: Application and progress.Frontiers in oncology · 2022Review
- Functional avoidance-based intensity modulated proton therapy with 4DCT derived ventilation imaging for lung cancer.Journal of applied clinical medical physics · 2021Article
- Functional perfusion image guided radiation treatment planning for locally advanced lung cancer.Physics and imaging in radiation oncology · 2019Article
- Robust CT ventilation from the integral formulation of the Jacobian.Medical physics · 2019Article
- Characterizing Spatial Lung Function for Esophageal Cancer Patients Undergoing Radiation Therapy.International journal of radiation oncology, biology, physics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
introduction4DCT-ventilation is an exciting new imaging modality that uses 4DCT data to calculate lung-function maps. Because 4DCTs are acquired as standard of care for lung cancer patients undergoing radiotherapy, 4DCT-ventiltation provides functional information at no extra dosimetric or monetary cost to the patient. The development of clinical trials is underway to use 4DCT-ventilation imaging to spare functional lung in patients undergoing radiotherapy. The purpose of this work was to perform a virtual trial using retrospective data to develop the practical aspects of a 4DCT-ventilation functional avoidance clinical trial.
methodsThe study included 96 stage III lung cancer patients. A 4DCT-ventilation map was calculated using the patient's 4DCT-imaging, deformable registration, and a density-change-based algorithm. Clinical trial inclusion assessment used quantitative and qualitative metrics based on the patient's spatial ventilation profile. Clinical and functional plans were generated for 25 patients. The functional plan aimed to reduce dose to functional lung while meeting standard target and critical structure constraints. Standard and dose-function metrics were compared between the clinical and functional plans.
resultsOur data showed that 69% and 59% of stage III patients have regional variability in function based on qualitative and quantitative metrics, respectively. Functional planning demonstrated an average reduction of 2.8 Gy (maximum 8.2 Gy) in the mean dose to functional lung.
conclusionsOur work demonstrated that 60-70% of stage III patients would be eligible for functional planning and that a typical functional lung mean dose reduction of 2.8 Gy can be expected relative to standard clinical plans. These findings provide salient data for the development of functional clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.