ArticleThe Journal of physiology2017
Direct current stimulation boosts synaptic gain and cooperativity in vitro.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Combination of non-invasive brain stimulation with mindfulness-based interventions for anxiety and depression symptoms: systematic review and meta-analysis of randomized controlled trials.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects.Frontiers in neuroscience · 2022Pooled it
- Transcranial direct current stimulation enhances delayed retention after 5 days of lower-limb motor skill learning.The Journal of physiology · 2026Trial
- Contextual Engagement to Enhance Effective Transcranial Direct Current Stimulation: A Theoretical and Mechanistic Perspective.Focus (American Psychiatric Publishing) · 2026Article
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
- Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects.Bioelectromagnetics · 2025Review
- Physical activity and anodal-transcranial direct current stimulation: a synergistic approach to boost motor cortex plasticity.Brain communications · 2025Article
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- Effects of Catecholaminergic and Transcranial Direct Current Stimulation on Response Inhibition.The international journal of neuropsychopharmacology · 2024Article
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Direct Current Stimulation Modulates Synaptic Facilitation via Distinct Presynaptic Calcium Channels.International journal of molecular sciences · 2023Article
- Multi-scale multi-physics model of brain interstitial water flux by transcranial Direct Current Stimulation.Journal of neural engineering · 2023Article
- A microfluidic perspective on conventional in vitro transcranial direct current stimulation methods.Journal of neuroscience methods · 2023Review
- Review
- Is there a neuroscience-based, mechanistic rationale for transcranial direct current stimulation as an adjunct treatment for posttraumatic stress disorder?Behavioral neuroscience · 2021Review
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Anodal tDCS modulates specific processing codes during conflict monitoring associated with superior and middle frontal cortices.Brain structure & function · 2021Article
- From adults to pediatrics: A review noninvasive brain stimulation (NIBS) to facilitate recovery from brain injury.Progress in brain research · 2021Review
- Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis.Brain sciences · 2020Article
- Spinal cord stimulation for the restoration of bladder function after spinal cord injury.Healthcare technology letters · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
key pointsDirect current stimulation (DCS) polarity specifically modulates synaptic efficacy during a continuous train of presynaptic inputs, despite synaptic depression. DCS polarizes afferent axons and postsynaptic neurons, boosting cooperativity between synaptic inputs. Polarization of afferent neurons in upstream brain regions may modulate activity in the target brain region during transcranial DCS (tDCS). A statistical theory of coincident activity predicts that the diffuse and weak profile of current flow can be advantageous in enhancing connectivity between co-active brain regions. ABSTRACT: Transcranial direct current stimulation (tDCS) produces sustained and diffuse current flow in the brain with effects that are state dependent and outlast stimulation. A mechanistic explanation for tDCS should capture these spatiotemporal features. It remains unclear how sustained DCS affects ongoing synaptic dynamics and how modulation of afferent inputs by diffuse stimulation changes synaptic activity at the target brain region. We tested the effect of acute DCS (10-20 V m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.