Evidence map›Paper›PMID 28435996›Full record

ReviewCurrent environmental health reports2017

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings.

J L Allen, C Klocke, K Morris-Schaffer, K Conrad, M Sobolewski, D A Cory-Slechta

Abstract readReview
In one paragraph

Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J L AllenDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
C KlockeDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
K Morris-SchafferDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
K ConradDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
M SobolewskiDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
D A Cory-SlechtaBox EHSC, University of Rochester Medical Center, Rochester, NY, 14642, USA. deborah_cory-slechta@urmc.rochester.edu.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
Developmental Exposures to Inhaled Air Pollution and the Autism Phenotype in MiceR01ES025541 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2015 to 2019
$2.2M
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES025541NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

purpose of reviewThis review sought to address the potential for air pollutants to impair cognition and mechanisms by which that might occur. RECENT

findingsAir pollution has been associated with deficits in cognitive functions across a wide range of epidemiological studies, both with developmental and adult exposures. Studies in animal models are significantly more limited in number, with somewhat inconsistent findings to date for measures of learning, but show more consistent impairments for short-term memory. Potential contributory mechanisms include oxidative stress/inflammation, altered levels of dopamine and/or glutamate, and changes in synaptic plasticity/structure. Epidemiological studies are consistent with adverse effects of air pollutants on cognition, but additional studies and better phenotypic characterization are needed for animal models, including more precise delineation of specific components of cognition that are affected, as well as definitions of critical exposure periods for such effects and the components of air pollution responsible. This would permit development of more circumscribed hypotheses as to potential behavioral and neurobiological mechanisms.

Indexed as

Air PollutantsAir PollutionAnimalsAttentionCognitionEnvironmental ExposureHumansInflammationMemory, Short-TermMiceNeuronal PlasticityAir PollutantsAir pollutionAttentionGlutamateInflammationLearningMemory

Identifiers

PMID28435996
PMCPMC5499513

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.