ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017
Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Circulating non-esterified fatty acids, risk of dementia and cognitive decline: The cardiovascular health study and multi-ethnic study of atherosclerosis.Neurobiology of aging · 2025Article
- Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis.JAMA network open · 2024Article
- An assessment of the mediating role of hypertension in the effect of long-term air pollution exposure on dementia.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Change in cardiovascular health and rate of cognitive decline in older adults: a 15-year population-based study.BMC geriatrics · 2024Article
- Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA).Scientific reports · 2024Article
- Long-term exposure to ambient air pollution and cognitive function in older US adults: The Multi-Ethnic Study of Atherosclerosis.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study.Alzheimer's research & therapy · 2022Article
- Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- High visit-to-visit blood pressure variability predicts global cognitive decline: The Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- DASH diet adherence and cognitive function: Multi-ethnic study of atherosclerosis.Clinical nutrition ESPEN · 2021Article
- Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Is Midlife Metabolic Syndrome Associated With Cognitive Function Change? The Study of Women's Health Across the Nation.The Journal of clinical endocrinology and metabolism · 2020Article
- In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Article
- Diastolic Blood Pressure and Cognitive Functioning: Differences by Systolic Blood Pressure Among US Adults.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWe examined whether changes in metabolic factors over 10 years were associated with cognitive performance.
methodsParticipants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing.
resultsAmong 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the
conclusionsCognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.