ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2017
Thermally Activated Delayed Fluorescence Organic Dots (TADF Odots) for Time-Resolved and Confocal Fluorescence Imaging in Living Cells and In Vivo.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Time-resolved image-guided Type-I photosensitization using a delayed fluorescent emitter.Chemical science · 2026Article
- Enhancing biological imaging with high-performance probes based on thermally activated delayed fluorescence.iScience · 2025Review
- Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging.Current medicinal chemistry · 2025Review
- The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation.Chemical reviews · 2024Review
- Conformational Control of Donor-Acceptor Molecules Using Non-covalent Interactions.The journal of physical chemistry. A · 2024Article
- Thermal control over phosphorescence or thermally activated delayed fluorescence in a metal-organic framework.Chemical science · 2024Article
- Cell-penetrating peptides noncovalently modified red phosphorescent nanoparticles for high-efficiency imaging.RSC advances · 2024Article
- Unveiling autophagy and aging through time-resolved imaging of lysosomal polarity with a delayed fluorescent emitter.Chemical science · 2023Article
- Supramolecular Assemblies Showing Thermally Activated Delayed Fluorescence.Small science · 2021Article
- Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal-Free Luminophores for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- New Cy5 photosensitizers for cancer phototherapy: a low singlet-triplet gap provides high quantum yield of singlet oxygen.Chemical science · 2021Article
- Degradation of Drug Delivery Nanocarriers and Payload Release: A Review of Physical Methods for Tracing Nanocarrier Biological Fate.Pharmaceutics · 2021Review
- Applying TADF Emitters in Bioimaging and Sensing-A Novel Approach Using Liposomes for Encapsulation and Cellular Uptake.Frontiers in chemistry · 2021Article
- Design, synthesis and application in biological imaging of a novel red fluorescent dye based on a rhodanine derivative.RSC advances · 2020Article
- TADF Dye-Loaded Nanoparticles for Fluorescence Live-Cell Imaging.Frontiers in chemistry · 2020Article
- Recent Developments on Multi-Functional Metal-Free Mechanochromic Luminescence and Thermally Activated Delayed Fluorescence Organic Materials.Frontiers in chemistry · 2020Review
- Stimuli-Responsive Thermally Activated Delayed Fluorescence in Polymer Nanoparticles and Thin Films: Applications in Chemical Sensing and Imaging.Frontiers in chemistry · 2020Review
- Sensitizing TADF Absorption Using Variable Length Oligo(phenylene ethynylene) Antennae.Frontiers in chemistry · 2020Article
- Hydrophilic, Red-Emitting, and Thermally Activated Delayed Fluorescence Emitter for Time-Resolved Luminescence Imaging by Mitochondrion-Induced Aggregation in Living Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Organic emitter integrating aggregation-induced delayed fluorescence and room-temperature phosphorescence characteristics, and its application in time-resolved luminescence imaging.Chemical science · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fluorophores with long-lived fluorescent emission are highly desirable for time-resolved fluorescence imaging (TRFI) in monitoring target fluorescence. By embedding the aggregates of a thermally activated delayed fluorescence (TADF) dye, 2,3,5,6-tetracarbazole-4-cyano-pyridine (CPy), in distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG2000) matrix, CPy-based organic dots (CPy-Odots) with a long fluorescence lifetime of 9.3 μs (in water at ambient condition) and high brightness (with an absolute fluorescence quantum efficiency of 38.3%) are fabricated. CPy-Odots are employed in time-resolved and confocal fluorescence imaging in living Hela cells and in vivo. The green emission from the CPy-Odots is readily differentiated from the cellular autofluorescence background because of their stronger emission intensities and longer lifetimes. Unlike other widely studied DSPE-PEG2000 encapsulated Odots which are always distributed in cytoplasm, CPy-Odots are located mainly in plasma membrane. In addition, the application of CPy-Odots as a bright microangiography agent for TRFI in zebrafish is also demonstrated. Much broader application of CPy-Odots is also prospected after further surface functionalization. Given its simplicity, high fluorescence intensity, and wide availability of TADF materials, the method can be extended to develop more excellent TADF Odots for accomplishing the challenges in future bioimaging applications.
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