Evidence map›Paper›PMID 28435767›Full record

ArticleEnvironmental sciences Europe2017

Green Toxicology: a strategy for sustainable chemical and material development.

Sarah E Crawford, Thomas Hartung, Henner Hollert, Björn Mathes, Bennard van Ravenzwaay, Thomas Steger-Hartmann, Christoph Studer, Harald F Krug

Abstract readEditorial
In one paragraph

Article in Environmental sciences Europe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. AI snake oil? A risk/benefit analysis for toxicology.Frontiers in artificial intelligence · 2026
    Article
  4. Review
  5. Review
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  7. Review
  8. Review
  9. Review
  10. Article
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  12. Article
  13. The Repellent Capacity againstMolecules (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah E CrawfordInstitute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
Thomas HartungJohn Hopkins University, Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205 USA.
Henner HollertInstitute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
Björn MathesDECHEMA e.V., Theodor-Heuss-Allee 25, 60486 Frankfurt, Germany.
Bennard van RavenzwaayBASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany.
Thomas Steger-HartmannInvestigational Toxicology, Bayer AG, Müllerstraße 178, 13352 Berlin, Germany.
Christoph StuderFederal Office of Public Health, Schwarzenburgstraße 157, 3003 Bern, Switzerland.
Harald F KrugEmpa, Materials Science and Technology, Lerchenfeld-straße 5, 9014 St. Gallen, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of "Green Chemistry" and "Green Engineering", "Green Toxicology" aims to shape future manufacturing processes and safe synthesis of chemicals in terms of environmental and human health impacts. Being an integral part of Green Chemistry, the principles of Green Toxicology amplify the role of health-related aspects for the benefit of consumers and the environment, in addition to being economical for manufacturing companies. Due to the costly development and preparation of new materials and chemicals for market entry, it is no longer practical to ignore the safety and environmental status of new products during product development stages. However, this is only possible if toxicologists and chemists work together early on in the development of materials and chemicals to utilize safe design strategies and innovative in vitro and in silico tools. This paper discusses some of the most relevant aspects, advances and limitations of the emergence of Green Toxicology from the perspective of different industry and research groups. The integration of new testing methods and strategies in product development, testing and regulation stages are presented with examples of the application of in silico, omics and in vitro methods. Other tools for Green Toxicology, including the reduction of animal testing, alternative test methods, and read-across approaches are also discussed.

Indexed as

Alternative animal testingGreen ChemistryGreen ToxicologyIn vitro assaysPredictive toxicologyToxicogenomics

Identifiers

PMID28435767
PMCPMC5380705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.