Evidence map›Paper›PMID 28435529›Full record

ArticleACS medicinal chemistry letters2017

Hiroyuki Kimura, Haruka Okuda, Masumi Ishiguro, Kenji Arimitsu, Akira Makino, Ryuichi Nishii, Anna Miyazaki, Yusuke Yagi, Hiroyuki Watanabe, Ikuo Kawasaki and 2 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Current topics in medicinal chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiroyuki KimuraGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Haruka OkudaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Masumi IshiguroSchool of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Hyogo 663-8179, Japan.
Kenji ArimitsuDepartment of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.
Akira MakinoBiomedical Imaging Research Center (BIRC), University of Fukui, Fukui 910-1193, Japan.
Ryuichi NishiiNational Institute of Radiological Sciences, Chiba 263-8555, Japan.
Anna MiyazakiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Yusuke YagiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Hiroyuki WatanabeGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Ikuo KawasakiSchool of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Hyogo 663-8179, Japan.
Masahiro OnoGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Hideo SajiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In nonsmall-cell lung carcinoma patients, L858R mutation of epidermal growth factor receptor (EGFR) is often found, and molecular target therapy using EGFR tyrosine kinase inhibitors is effective for the patients. However, the treatment frequently develops drug resistance by secondary mutation, of which approximately 50% is T790M mutation. Therefore, the ability to predict whether EGFR will undergo secondary mutation is extremely important. We synthesized a novel radiofluorinated 4-(anilino)pyrido[3,4-

Indexed as

4-(anilino)pyrido[3,4-d]pyrimidineEpidermal growth factor receptor tyrosine kinase (EGFR-TK)fluorin-18L858R mutant EGFRpositron emission tomography

Identifiers

PMID28435529
PMCPMC5392762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.