Evidence map›Paper›PMID 28435526›Full record

ArticleACS medicinal chemistry letters2017

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

Adrian L Pietkiewicz, Yuqi Zhang, Marwa N Rahimi, Michael Stramandinoli, Matthew Teusner, Shelli R McAlpine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adrian L PietkiewiczSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Yuqi ZhangSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Marwa N RahimiSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Michael StramandinoliSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Matthew TeusnerSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Shelli R McAlpineSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
UNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds

Indexed as

antitumorc-MycHeterocycleMcl-1p53RITAthiazole

Identifiers

PMID28435526
PMCPMC5392768
OpenAlexW2594929327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.