Evidence map›Paper›PMID 28435523›Full record

ArticleACS medicinal chemistry letters2017

Discovery of [1,2,3]Triazolo[4,5-

Zhong-Hua Li, Xue-Qi Liu, Peng-Fei Geng, Feng-Zhi Suo, Jin-Lian Ma, Bin Yu, Tao-Qian Zhao, Zhao-Qing Zhou, Chen-Xi Huang, Yi-Chao Zheng and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Discovery of [1,2,3]triazolo[4,5-Acta pharmaceutica Sinica. B · 2020
    Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhong-Hua LiKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Xue-Qi LiuKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Peng-Fei GengKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Feng-Zhi SuoKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Jin-Lian MaKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Bin YuKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Tao-Qian ZhaoKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zhao-Qing ZhouKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Chen-Xi HuangKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Yi-Chao ZhengKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Hong-Min LiuKey Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation. The aberrant overexpression of LSD1 has been reported to be involved in the progression of certain human malignant tumors. Abrogation of LSD1 with RNAi or small molecule inhibitors may lead to the inhibition of cancer proliferation and migration. Herein, a series of [1,2,3]triazolo[4,5-

Indexed as

[1,2,3]Triazolo[4,5-d]pyrimidineLSD1 inhibitormigration inhibitionmolecular docking

Identifiers

PMID28435523
PMCPMC5392756
OpenAlexW2593302066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.