Evidence map›Paper›PMID 28435464›Full record

Trial reportTheranostics2017

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin.

Martin Metz, Petra Staubach, Andrea Bauer, Randolf Brehler, Janine Gericke, Michael Kangas, Joanna Ashton-Chess, Philip Jarvis, Panayiotis Georgiou, Janice Canvin and 3 more

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Comparative efficacy and safety of the treatment by Omalizumab for chronic idiopathic urticaria in the general population: A systematic review and network meta-analysis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Pooled it
  5. Response of FcεRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Trial
  6. Trial
  7. Review
  8. Review
  9. Omalizumab in Refractory Adult-Onset Facial Atopic Dermatitis: A Case Report.Clinical, cosmetic and investigational dermatology · 2026
    Article
  10. Article
  11. Spectrum and Impact of Reported Side Effects of Omalizumab in Patients With Chronic Urticaria: A Long-Term Multicentre Real-World Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Research hotspots in urticaria: A bibliometric study of the top 100 most cited articles.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Martin MetzDepartment of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.
Petra StaubachDepartment of Dermatology, University Medicine Mainz, Germany.
Andrea BauerDepartment of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Germany.
Randolf BrehlerDepartment of Dermatology, University Hospital Muenster, Germany.
Janine GerickeDepartment of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.
Michael KangasTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Joanna Ashton-ChessTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Philip JarvisTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Panayiotis GeorgiouTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Janice CanvinTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Rainer HillenbrandTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Veit J ErpenbeckTranslational Medicine, Novartis Pharma AG, Basel, Switzerland.
Marcus MaurerDepartment of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.
Novartis (Switzerland) · CHCharité - Universitätsmedizin Berlin · DEJohannes Gutenberg University Mainz · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAgedAnti-Allergic AgentsBasophilsDouble-Blind MethodHumansImmunoglobulin EInjections, SubcutaneousLeukocyte CountMiddle AgedOmalizumabPlacebosReceptors, IgESkinTreatment OutcomeAnti-Allergic AgentsFcepsilonRI alpha-chain, humanImmunoglobulin EOmalizumabPlacebosReceptors, IgEChronic Spontaneous urticariamode of actionOmalizumab

Identifiers

PMID28435464
PMCPMC5399592
OpenAlexW2596128663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.