Evidence map›Paper›PMID 28435459›Full record

ArticleTheranostics2017

Aptamer Internalization via Endocytosis Inducing S-Phase Arrest and Priming Maver-1 Lymphoma Cells for Cytarabine Chemotherapy.

Huan Li, Shuanghui Yang, Ge Yu, Liangfang Shen, Jia Fan, Ling Xu, Hedong Zhang, Nianxi Zhao, Zihua Zeng, Tony Hu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Review
  6. Aptamer technology: a new approach to treat lymphoma?Blood science (Baltimore, Md.) · 2020
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Huan LiDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Shuanghui YangDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Ge YuDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Liangfang ShenDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jia FanDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Ling XuDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Hedong ZhangDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Nianxi ZhaoDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Zihua ZengDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Tony HuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Jianguo WenDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Youli ZuDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Methodist Hospital · USHouston Methodist · USCentral South University · CNJilin University · CNXiangya Hospital Central South University · CN

Funding

A bifunctional nanomedicine for both specific imaging and targeting therapy of anR01CA151955 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ZU, YOULI · 2010 to 2014
$1.5M
RFA-CA -12-003 - Activatable One-Drop and One-Step Assay for Circulating Tumor CeR33CA173382 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ZU, YOULI · 2012 to 2014
$1.1M
NCI NIH HHS R01 CA151955NCI NIH HHS R33 CA173382
6 · The paper itself

Abstract

The goal of precision therapy is to efficiently treat cancer without side effects. Aptamers are a class of small ligands composed of single-stranded oligonucleotides that bind to their targets with high affinity and specificity. In this study, we identified an ssDNA aptamer specifically targeting Maver-1 lymphoma cells with high binding affinity (K

Indexed as

Cell Cycle CheckpointsEndocytosisAntimetabolites, AntineoplasticAptamers, NucleotideB-LymphocytesCell Line, TumorCell ProliferationCytarabineHumansAntimetabolites, AntineoplasticAptamers, NucleotideCytarabineaptamerbiotherapeuticslymphomaS-phase arrestsynergistic chemotherapy

Identifiers

PMID28435459
PMCPMC5399587
OpenAlexW2596035704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.