ArticleThe Journal of cell biology1988
Signal transduction in Dictyostelium fgd A mutants with a defective interaction between surface cAMP receptors and a GTP-binding regulatory protein.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 124 citations in OpenAlex.
- Forty-five years of cGMP research inMolecular biology of the cell · 2021Review
- The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation.Developmental biology · 2013Article
- A RabGAP regulates life-cycle duration via trimeric G-protein cascades in Dictyostelium discoideum.PloS one · 2013Article
- A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium.Eukaryotic cell · 2007Article
- A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils.Molecular biology of the cell · 2007Article
- A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium.Molecular biology of the cell · 1998Article
- Selection of gbeta subunits with point mutations that fail to activate specific signaling pathways in vivo: dissecting cellular responses mediated by a heterotrimeric G protein in Dictyostelium discoideum.Molecular biology of the cell · 1998Article
- A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.Genes & development · 1997Article
- The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium.The Journal of cell biology · 1996Article
- Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells.Experientia · 1995Review
- Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes.The Journal of cell biology · 1995Article
- The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.The Journal of cell biology · 1995Article
- A density-sensing factor regulates signal transduction in Dictyostelium.The Journal of cell biology · 1995Article
- Transmembrane signalling in eukaryotes: a comparison between higher and lower eukaryotes.Plant molecular biology · 1994Review
- The G alpha subunit G alpha 4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.The Journal of cell biology · 1994Article
- Developmental decisions in Dictyostelium discoideum.Microbiological reviews · 1994Review
- Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium.Molecular biology of the cell · 1994Article
- Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.The EMBO journal · 1994Article
- Spatial and temporal expression of the Dictyostelium discoideum G alpha protein subunit G alpha 2: expression of a dominant negative protein inhibits proper prestalk to stalk differentiation.Molecular biology of the cell · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane signal transduction was investigated in four Dictyostelium discoideum mutants that belong to the fgd A complementation group. The results show the following. (a) Cell surface cAMP receptors are present in fgd A mutants, but cAMP does not induce any of the intracellular responses, including the activation of adenylate or guanylate cyclase and chemotaxis. (b) cAMP induces down-regulation and the covalent modification (presumably phosphorylation) of the cAMP receptor. (c) The inhibitory effects of GTP gamma S and GDP beta S on cAMP binding are reduced; the stimulatory effect of cAMP on GTP gamma S binding is lost in fgd A mutants. (d) Basal high-affinity GTPase activity is reduced 40% and the stimulatory effect of cAMP is decreased from 40% in wild type to 30% in fgd A. (e) GTP-mediated stimulation and inhibition of adenylate cyclase is normal in mutant membranes. The results suggest a defective interaction between cell surface cAMP receptors and a specific G-protein in fgd A mutants. This interaction appears to be essential for nearly all signal transduction pathways in Dictyostelium discoideum.
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