ArticleContemporary oncology (Poznan, Poland)2017
Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer.
Article in Contemporary oncology (Poznan, Poland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2023Pooled it
- Genetic alterations inFrontiers in oncology · 2023Pooled it
- Investigation ofBioscience reports · 2019Pooled it
- Pooled it
- Association between serum leptin levels and breast cancer risk: An updated systematic review and meta-analysis.Medicine · 2018Pooled it
- Association of Leptin Receptor Q223R Gene Polymorphism and Breast Cancer Patients: A Case Control Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case-Control Study in Chinese Females.Frontiers in oncology · 2022Article
- Leptin, Both Bad and Good Actor in Cancer.Biomolecules · 2021Review
- LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.Molecular biology reports · 2021Article
- The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Leptin Levels and Q223R Leptin Receptor Gene Polymorphism in Obese Mexican Young Adults.EJIFCC · 2020Article
- A Review of Cancer Genetics and Genomics Studies in Africa.Frontiers in oncology · 2020Review
- Leptin-induced signaling pathways in cancer cell migration and invasion.Cellular oncology (Dordrecht, Netherlands) · 2019Review
- Signaling Pathways Induced by Leptin during Epithelial⁻Mesenchymal Transition in Breast Cancer.International journal of molecular sciences · 2018Review
- Obesity phenotype in relation to gene polymorphism among samples of Egyptian children and their mothers.Genes & diseases · 2018Article
- Investigation ofOncotarget · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studyBreast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women. It induces chronic inflammation, which increases local and systemic levels of cytokines and adipokines such as leptin. Leptin (LEP) and leptin receptor (LEPR) genes have several polymorphisms in humans. This study aims to assess the association between blood levels of leptin and LEPR Q223R gene polymorphism in patients of cancer breast. MATERIAL AND
methodsThe current study was carried on 48 female breast cancer patients and 48 heathy female subjects. Carcinoembryonic antigen (CEA), cancer antibody CA15-3, and leptin hormone were determined. Single nucleotide polymorphism of LEPR Q223R was assessed by PCR/RFLP. Statistical analysis used: The statistical analysis of data was done by using SPSS version 20.
resultsThere were significant increases in the concentrations of CEA (
conclusionsLeptin hormone shows significantly higher concentrations in BC patients. As regard to LEPR Q223R gene polymorphism, AA genotype showed significantly higher frequency in BC patients.
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