Evidence map›Paper›PMID 28435295›Full record

ArticleOncoTargets and therapy2017

Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.

Wentao Tang, Meiling Ji, Guodong He, Liangliang Yang, Zhengchuan Niu, Mi Jian, Ye Wei, Li Ren, Jianmin Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 4 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.

  1. Pooled it
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  11. Circular RNA in cancer.Nature reviews. Cancer · 2024
    Review
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wentao TangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Meiling JiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Guodong HeDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Liangliang YangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Zhengchuan NiuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Mi JianDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Ye WeiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Li RenDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Jianmin XuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies have demonstrated that circular RNAs (circRNAs) can regulate gene expression through interacting with microRNAs. In this study, we analyzed the expression of antisense to CDR1as in colorectal cancer (CRC). CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown. Mechanistic studies demonstrated that CDR1as silencing suppressed EGFR and IGF-1R expression, which could be partially blocked by the miR-7 inhibitor. Finally, positive correlations between CDR1as expression and

Indexed as

CDR1ascolorectal cancermicroRNA-7proliferation

Identifiers

PMID28435295
PMCPMC5391170
OpenAlexW2604647093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.